Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing

Adoptive T cell therapy (ACT) is highly effective in the treatment of hematologic malignancies, but shows limited success in solid tumors. Inactivation of T cells in the tumor milieu is a major hurdle to a wider application of ACT. Cytotoxicity is the most relevant activity for tumor eradication. He...

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Detalles Bibliográficos
Autores principales: Fischbeck, Angelika J., Ruehland, Svenja, Ettinger, Andreas, Paetzold, Kerstin, Masouris, Ilias, Noessner, Elfriede, Mendler, Anna N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753121/
https://www.ncbi.nlm.nih.gov/pubmed/33364193
http://dx.doi.org/10.3389/fonc.2020.589434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753121/
https://www.ncbi.nlm.nih.gov/pubmed/33364193
http://dx.doi.org/10.3389/fonc.2020.589434

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