Therapeutic advances of miRNAs: A preclinical and clinical update

miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companie...

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Autores principales: Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Sharma, Garima, Lee, Sang-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753224/
https://www.ncbi.nlm.nih.gov/pubmed/33364050
http://dx.doi.org/10.1016/j.jare.2020.08.012
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author Chakraborty, Chiranjib
Sharma, Ashish Ranjan
Sharma, Garima
Lee, Sang-Soo
author_facet Chakraborty, Chiranjib
Sharma, Ashish Ranjan
Sharma, Garima
Lee, Sang-Soo
author_sort Chakraborty, Chiranjib
collection PubMed
description miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated.
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spelling pubmed-77532242020-12-23 Therapeutic advances of miRNAs: A preclinical and clinical update Chakraborty, Chiranjib Sharma, Ashish Ranjan Sharma, Garima Lee, Sang-Soo J Adv Res Article miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated. Elsevier 2020-08-29 /pmc/articles/PMC7753224/ /pubmed/33364050 http://dx.doi.org/10.1016/j.jare.2020.08.012 Text en © 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chakraborty, Chiranjib
Sharma, Ashish Ranjan
Sharma, Garima
Lee, Sang-Soo
Therapeutic advances of miRNAs: A preclinical and clinical update
title Therapeutic advances of miRNAs: A preclinical and clinical update
title_full Therapeutic advances of miRNAs: A preclinical and clinical update
title_fullStr Therapeutic advances of miRNAs: A preclinical and clinical update
title_full_unstemmed Therapeutic advances of miRNAs: A preclinical and clinical update
title_short Therapeutic advances of miRNAs: A preclinical and clinical update
title_sort therapeutic advances of mirnas: a preclinical and clinical update
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753224/
https://www.ncbi.nlm.nih.gov/pubmed/33364050
http://dx.doi.org/10.1016/j.jare.2020.08.012
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