High grade transformation of adenoid cystic carcinoma in the palate: Case report with review of literature

INTRODUCTION: Adenoid cystic carcinoma (ACC) is a rare tumor developed in minor salivary glands, the palate being the most common site. CASE PRESENTATION: Here, we report a case of a 58-year-old man with a 3-year-growing swelling in the right palate diagnosed with high grade transformation adenoid c...

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Detalles Bibliográficos
Autores principales: Ahlem, Bchir, Manel, Njima, Nouha, Ben Abdeljalil, Seiffeddine, Ben Hammouda, Khalifa, Mighri, Leila, Njim, Abdelfateh, Zakhama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753240/
https://www.ncbi.nlm.nih.gov/pubmed/33352446
http://dx.doi.org/10.1016/j.ijscr.2020.12.014
Descripción
Sumario:INTRODUCTION: Adenoid cystic carcinoma (ACC) is a rare tumor developed in minor salivary glands, the palate being the most common site. CASE PRESENTATION: Here, we report a case of a 58-year-old man with a 3-year-growing swelling in the right palate diagnosed with high grade transformation adenoid cystic carcinoma. The exam revealed a 4 cm large mass. A tumor resection with a radical neck dissection was performed. DISCUSSION: High grade transformation in adenoid cystic carcinoma is recently described by Cheuk et al. in 1999. This transformation has more aggressive behavior than conventional solid ACC and has usually been associated with recurrences, early distant metastasis, and greater mortality. CONCLUSION: The aim here is to highlight clinical, histopathological, therapeutic and prognostic aspects of high-grade transformation in ACC with literature review.

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