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COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission

AIM: To assess predictors of in‐hospital mortality in people with prediabetes and diabetes hospitalized for COVID‐19 infection and to develop a risk score for identifying those at the greatest risk of a fatal outcome. MATERIALS AND METHODS: A combined prospective and retrospective, multicentre, coho...

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Autores principales: Sourij, Harald, Aziz, Faisal, Bräuer, Alexander, Ciardi, Christian, Clodi, Martin, Fasching, Peter, Karolyi, Mario, Kautzky‐Willer, Alexandra, Klammer, Carmen, Malle, Oliver, Oulhaj, Abderrahim, Pawelka, Erich, Peric, Slobodan, Ress, Claudia, Sourij, Caren, Stechemesser, Lars, Stingl, Harald, Stulnig, Thomas, Tripolt, Norbert, Wagner, Michael, Wolf, Peter, Zitterl, Andreas, Kaser, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753560/
https://www.ncbi.nlm.nih.gov/pubmed/33200501
http://dx.doi.org/10.1111/dom.14256
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author Sourij, Harald
Aziz, Faisal
Bräuer, Alexander
Ciardi, Christian
Clodi, Martin
Fasching, Peter
Karolyi, Mario
Kautzky‐Willer, Alexandra
Klammer, Carmen
Malle, Oliver
Oulhaj, Abderrahim
Pawelka, Erich
Peric, Slobodan
Ress, Claudia
Sourij, Caren
Stechemesser, Lars
Stingl, Harald
Stulnig, Thomas
Tripolt, Norbert
Wagner, Michael
Wolf, Peter
Zitterl, Andreas
Kaser, Susanne
author_facet Sourij, Harald
Aziz, Faisal
Bräuer, Alexander
Ciardi, Christian
Clodi, Martin
Fasching, Peter
Karolyi, Mario
Kautzky‐Willer, Alexandra
Klammer, Carmen
Malle, Oliver
Oulhaj, Abderrahim
Pawelka, Erich
Peric, Slobodan
Ress, Claudia
Sourij, Caren
Stechemesser, Lars
Stingl, Harald
Stulnig, Thomas
Tripolt, Norbert
Wagner, Michael
Wolf, Peter
Zitterl, Andreas
Kaser, Susanne
author_sort Sourij, Harald
collection PubMed
description AIM: To assess predictors of in‐hospital mortality in people with prediabetes and diabetes hospitalized for COVID‐19 infection and to develop a risk score for identifying those at the greatest risk of a fatal outcome. MATERIALS AND METHODS: A combined prospective and retrospective, multicentre, cohort study was conducted at 10 sites in Austria in 247 people with diabetes or newly diagnosed prediabetes who were hospitalized with COVID‐19. The primary outcome was in‐hospital mortality and the predictor variables upon admission included clinical data, co‐morbidities of diabetes or laboratory data. Logistic regression analyses were performed to identify significant predictors and to develop a risk score for in‐hospital mortality. RESULTS: The mean age of people hospitalized (n = 238) for COVID‐19 was 71.1 ± 12.9 years, 63.6% were males, 75.6% had type 2 diabetes, 4.6% had type 1 diabetes and 19.8% had prediabetes. The mean duration of hospital stay was 18 ± 16 days, 23.9% required ventilation therapy and 24.4% died in the hospital. The mortality rate in people with diabetes was numerically higher (26.7%) compared with those with prediabetes (14.9%) but without statistical significance (P = .128). A score including age, arterial occlusive disease, C‐reactive protein, estimated glomerular filtration rate and aspartate aminotransferase levels at admission predicted in‐hospital mortality with a C‐statistic of 0.889 (95% CI: 0.837‐0.941) and calibration of 1.000 (P = .909). CONCLUSIONS: The in‐hospital mortality for COVID‐19 was high in people with diabetes but not significantly different to the risk in people with prediabetes. A risk score using five routinely available patient variables showed excellent predictive performance for assessing in‐hospital mortality.
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spelling pubmed-77535602020-12-22 COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission Sourij, Harald Aziz, Faisal Bräuer, Alexander Ciardi, Christian Clodi, Martin Fasching, Peter Karolyi, Mario Kautzky‐Willer, Alexandra Klammer, Carmen Malle, Oliver Oulhaj, Abderrahim Pawelka, Erich Peric, Slobodan Ress, Claudia Sourij, Caren Stechemesser, Lars Stingl, Harald Stulnig, Thomas Tripolt, Norbert Wagner, Michael Wolf, Peter Zitterl, Andreas Kaser, Susanne Diabetes Obes Metab Original Articles AIM: To assess predictors of in‐hospital mortality in people with prediabetes and diabetes hospitalized for COVID‐19 infection and to develop a risk score for identifying those at the greatest risk of a fatal outcome. MATERIALS AND METHODS: A combined prospective and retrospective, multicentre, cohort study was conducted at 10 sites in Austria in 247 people with diabetes or newly diagnosed prediabetes who were hospitalized with COVID‐19. The primary outcome was in‐hospital mortality and the predictor variables upon admission included clinical data, co‐morbidities of diabetes or laboratory data. Logistic regression analyses were performed to identify significant predictors and to develop a risk score for in‐hospital mortality. RESULTS: The mean age of people hospitalized (n = 238) for COVID‐19 was 71.1 ± 12.9 years, 63.6% were males, 75.6% had type 2 diabetes, 4.6% had type 1 diabetes and 19.8% had prediabetes. The mean duration of hospital stay was 18 ± 16 days, 23.9% required ventilation therapy and 24.4% died in the hospital. The mortality rate in people with diabetes was numerically higher (26.7%) compared with those with prediabetes (14.9%) but without statistical significance (P = .128). A score including age, arterial occlusive disease, C‐reactive protein, estimated glomerular filtration rate and aspartate aminotransferase levels at admission predicted in‐hospital mortality with a C‐statistic of 0.889 (95% CI: 0.837‐0.941) and calibration of 1.000 (P = .909). CONCLUSIONS: The in‐hospital mortality for COVID‐19 was high in people with diabetes but not significantly different to the risk in people with prediabetes. A risk score using five routinely available patient variables showed excellent predictive performance for assessing in‐hospital mortality. Blackwell Publishing Ltd 2020-12-04 2021-02 /pmc/articles/PMC7753560/ /pubmed/33200501 http://dx.doi.org/10.1111/dom.14256 Text en © 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Sourij, Harald
Aziz, Faisal
Bräuer, Alexander
Ciardi, Christian
Clodi, Martin
Fasching, Peter
Karolyi, Mario
Kautzky‐Willer, Alexandra
Klammer, Carmen
Malle, Oliver
Oulhaj, Abderrahim
Pawelka, Erich
Peric, Slobodan
Ress, Claudia
Sourij, Caren
Stechemesser, Lars
Stingl, Harald
Stulnig, Thomas
Tripolt, Norbert
Wagner, Michael
Wolf, Peter
Zitterl, Andreas
Kaser, Susanne
COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission
title COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission
title_full COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission
title_fullStr COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission
title_full_unstemmed COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission
title_short COVID‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission
title_sort covid‐19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753560/
https://www.ncbi.nlm.nih.gov/pubmed/33200501
http://dx.doi.org/10.1111/dom.14256
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