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Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness

Given the global health burden caused by the Coronavirus Disease 2019 (COVID‐19), there have been numerous studies aimed to understand its clinical course and to determine risk factors that may impact prognosis. Pre‐existing medical conditions are linked with COVID‐19 severity, particularly cardiome...

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Detalles Bibliográficos
Autores principales: Sy‐Janairo, Marianne Linley, Y Cua, Ian Homer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753749/
https://www.ncbi.nlm.nih.gov/pubmed/33363258
http://dx.doi.org/10.1002/jgh3.12465
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author Sy‐Janairo, Marianne Linley
Y Cua, Ian Homer
author_facet Sy‐Janairo, Marianne Linley
Y Cua, Ian Homer
author_sort Sy‐Janairo, Marianne Linley
collection PubMed
description Given the global health burden caused by the Coronavirus Disease 2019 (COVID‐19), there have been numerous studies aimed to understand its clinical course and to determine risk factors that may impact prognosis. Pre‐existing medical conditions are linked with COVID‐19 severity, particularly cardiometabolic diseases. Increasing evidence has also linked metabolic‐associated fatty liver disease (MAFLD) with severe COVID‐19 illness. Thus, we review different published clinical data relating to the association of MAFLD and COVID‐19 severity. Our review showed that published studies consistently support the association between MAFLD and more severe COVID‐19, even after adjustment for confounding factors. It was also observed that an increasing hepatic fibrosis score is correlated with increasing severity of COVID‐19. Finally, younger age and obesity among MAFLD patients also led to a greater risk of severe illness.
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spelling pubmed-77537492020-12-22 Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness Sy‐Janairo, Marianne Linley Y Cua, Ian Homer JGH Open Review Articles Given the global health burden caused by the Coronavirus Disease 2019 (COVID‐19), there have been numerous studies aimed to understand its clinical course and to determine risk factors that may impact prognosis. Pre‐existing medical conditions are linked with COVID‐19 severity, particularly cardiometabolic diseases. Increasing evidence has also linked metabolic‐associated fatty liver disease (MAFLD) with severe COVID‐19 illness. Thus, we review different published clinical data relating to the association of MAFLD and COVID‐19 severity. Our review showed that published studies consistently support the association between MAFLD and more severe COVID‐19, even after adjustment for confounding factors. It was also observed that an increasing hepatic fibrosis score is correlated with increasing severity of COVID‐19. Finally, younger age and obesity among MAFLD patients also led to a greater risk of severe illness. Wiley Publishing Asia Pty Ltd 2020-12-01 /pmc/articles/PMC7753749/ /pubmed/33363258 http://dx.doi.org/10.1002/jgh3.12465 Text en © 2020 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Sy‐Janairo, Marianne Linley
Y Cua, Ian Homer
Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness
title Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness
title_full Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness
title_fullStr Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness
title_full_unstemmed Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness
title_short Association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness
title_sort association of metabolic‐associated fatty liver disease and risk of severe coronavirus disease 2019 illness
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753749/
https://www.ncbi.nlm.nih.gov/pubmed/33363258
http://dx.doi.org/10.1002/jgh3.12465
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