The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells

Metabolic reprogramming of tumour cells sustains cancer progression. Similar to other cancer cells, glioblastoma cells exhibit an increased glycolytic flow, which encourages the use of antiglycolytics as an effective complementary therapy. We used the antiglycolytic 3-bromopyruvate (3BP) as a metabo...

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Detalles Bibliográficos
Autores principales: Petricciuolo, Maya, Davidescu, Magdalena, Fettucciari, Katia, Gatticchi, Leonardo, Brancorsini, Stefano, Roberti, Rita, Corazzi, Lanfranco, Macchioni, Lara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753915/
https://www.ncbi.nlm.nih.gov/pubmed/33364504
http://dx.doi.org/10.1016/j.heliyon.2020.e05741

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