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Molecular docking‐assisted screening reveals tannic acid as a natural protein disulphide isomerase inhibitor with antiplatelet and antithrombotic activities

Protein disulphide isomerase (PDI) promotes platelet activation and constitutes a novel antithrombotic target. In this study, we reported that a PDI‐binding plant polyphenol, tannic acid (TA), inhibits PDI activity, platelet activation and thrombus formation. Molecular docking using plant polyphenol...

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Detalles Bibliográficos
Autores principales:	Ren, Lijie, You, Tao, Li, Qing, Chen, Guona, Liu, Ziting, Zhao, Xuefei, Wang, Yinyan, Wang, Lei, Wu, Yi, Tang, Chaojun, Zhu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753999/ https://www.ncbi.nlm.nih.gov/pubmed/33128352 http://dx.doi.org/10.1111/jcmm.16043

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