Metformin attenuates trauma‐induced heterotopic ossification via inhibition of Bone Morphogenetic Protein signalling

AMP‐activated protein kinase (AMPK) is an intracellular sensor of energy homoeostasis that is activated under energy stress and suppressed in energy surplus. AMPK activation leads to inhibition of anabolic processes that consume ATP. Osteogenic differentiation is a process that highly demands ATP du...

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Detalles Bibliográficos
Autores principales: Lin, Hui, Shi, Fuli, Jiang, Shanshan, Wang, Yuanyuan, Zou, Junrong, Ying, Ying, Huang, Deqiang, Luo, Lingyu, Yan, Xiaohua, Luo, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754007/
https://www.ncbi.nlm.nih.gov/pubmed/33169942
http://dx.doi.org/10.1111/jcmm.16076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754007/
https://www.ncbi.nlm.nih.gov/pubmed/33169942
http://dx.doi.org/10.1111/jcmm.16076

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