NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β‐cells for protection

Sustained hyperglycaemia and hyperlipidaemia incur endoplasmic reticulum stress (ER stress) and reactive oxygen species (ROS) overproduction in pancreatic β‐cells. ER stress or ROS causes c‐Jun N‐terminal kinase (JNK) activation, and the activated JNK triggers apoptosis in different cells. Nuclear r...

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Detalles Bibliográficos
Autores principales: Pu, Ze‐qing, Liu, Dong, Lobo Mouguegue, Hanse Pablick Patherny, Jin, Cheng‐wen, Sadiq, Esha, Qin, Dan‐dan, Yu, Tian‐fu, Zong, Chen, Chen, Ji‐cui, Zhao, Ru‐xing, Lin, Jing‐Yu, Cheng, Jie, Yu, Xiao, Li, Xia, Zhang, Yu‐chao, Liu, Yuan‐tao, Guan, Qing‐bo, Wang, Xiang‐dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754045/
https://www.ncbi.nlm.nih.gov/pubmed/33124187
http://dx.doi.org/10.1111/jcmm.16028

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