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Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence
Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8(+) T cell compartment and elevated plasma TNF‐α but in later follow‐up immune recovery comes into play. Whether the recovery phenotype is long lasting or transient remains to be elucidated, however, late adverse effect...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754117/ https://www.ncbi.nlm.nih.gov/pubmed/32744364 http://dx.doi.org/10.1002/eji.202048541 |
| _version_ | 1783626128801398784 |
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| author | Lázničková, Petra Kepák, Tomáš Hortová – Kohoutková, Marcela Horváth, Luděk Sheardová, Kateřina Marciniak, Rafal Vacca, Carmine Šiklová, Michaela Zelante, Teresa Rossmeislová, Lenka Křenová, Zdenka Štěrba, Jaroslav Bendíčková, Kamila Frič, Jan |
| author_facet | Lázničková, Petra Kepák, Tomáš Hortová – Kohoutková, Marcela Horváth, Luděk Sheardová, Kateřina Marciniak, Rafal Vacca, Carmine Šiklová, Michaela Zelante, Teresa Rossmeislová, Lenka Křenová, Zdenka Štěrba, Jaroslav Bendíčková, Kamila Frič, Jan |
| author_sort | Lázničková, Petra |
| collection | PubMed |
| description | Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8(+) T cell compartment and elevated plasma TNF‐α but in later follow‐up immune recovery comes into play. Whether the recovery phenotype is long lasting or transient remains to be elucidated, however, late adverse effects often occur in childhood cancer survivors. [Image: see text] |
| format | Online Article Text |
| id | pubmed-7754117 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77541172020-12-23 Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence Lázničková, Petra Kepák, Tomáš Hortová – Kohoutková, Marcela Horváth, Luděk Sheardová, Kateřina Marciniak, Rafal Vacca, Carmine Šiklová, Michaela Zelante, Teresa Rossmeislová, Lenka Křenová, Zdenka Štěrba, Jaroslav Bendíčková, Kamila Frič, Jan Eur J Immunol Letters to the Editor Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8(+) T cell compartment and elevated plasma TNF‐α but in later follow‐up immune recovery comes into play. Whether the recovery phenotype is long lasting or transient remains to be elucidated, however, late adverse effects often occur in childhood cancer survivors. [Image: see text] John Wiley and Sons Inc. 2020-08-18 2020-12 /pmc/articles/PMC7754117/ /pubmed/32744364 http://dx.doi.org/10.1002/eji.202048541 Text en © 2020 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Letters to the Editor Lázničková, Petra Kepák, Tomáš Hortová – Kohoutková, Marcela Horváth, Luděk Sheardová, Kateřina Marciniak, Rafal Vacca, Carmine Šiklová, Michaela Zelante, Teresa Rossmeislová, Lenka Křenová, Zdenka Štěrba, Jaroslav Bendíčková, Kamila Frič, Jan Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence |
| title | Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence |
| title_full | Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence |
| title_fullStr | Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence |
| title_full_unstemmed | Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence |
| title_short | Childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence |
| title_sort | childhood survivors of high‐risk neuroblastoma show signs of immune recovery and not immunosenescence |
| topic | Letters to the Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754117/ https://www.ncbi.nlm.nih.gov/pubmed/32744364 http://dx.doi.org/10.1002/eji.202048541 |
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