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Risk of selection bias due to non‐participation in a cohort study on pubertal timing

BACKGROUND: Non‐participation in aetiologic studies of pubertal timing is frequent. However, little effort has been given to explore the risk and potential impact of selection bias in studies of pubertal timing. OBJECTIVE: We aimed to explore the risk of selection bias due to non‐participation in a...

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Autores principales: Brix, Nis, Ernst, Andreas, Lauridsen, Lea Lykke Braskhøj, Parner, Erik Thorlund, Arah, Onyebuchi A., Olsen, Jørn, Henriksen, Tine Brink, Ramlau‐Hansen, Cecilia Høst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754153/
https://www.ncbi.nlm.nih.gov/pubmed/32319135
http://dx.doi.org/10.1111/ppe.12679
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author Brix, Nis
Ernst, Andreas
Lauridsen, Lea Lykke Braskhøj
Parner, Erik Thorlund
Arah, Onyebuchi A.
Olsen, Jørn
Henriksen, Tine Brink
Ramlau‐Hansen, Cecilia Høst
author_facet Brix, Nis
Ernst, Andreas
Lauridsen, Lea Lykke Braskhøj
Parner, Erik Thorlund
Arah, Onyebuchi A.
Olsen, Jørn
Henriksen, Tine Brink
Ramlau‐Hansen, Cecilia Høst
author_sort Brix, Nis
collection PubMed
description BACKGROUND: Non‐participation in aetiologic studies of pubertal timing is frequent. However, little effort has been given to explore the risk and potential impact of selection bias in studies of pubertal timing. OBJECTIVE: We aimed to explore the risk of selection bias due to non‐participation in a newly established puberty cohort. METHODS: We evaluated whether three maternal exposures chosen a priori (pre‐pregnancy obesity, smoking, and alcohol drinking during pregnancy) were associated with participation, whether pubertal timing was associated with participation, and whether selection bias influenced the associations between these exposures and pubertal timing. In total, 22 439 children from the Danish National Birth Cohort born 2000–2003 were invited to the Puberty Cohort and 15 819 (70%) participated. Exposures were self‐reported during pregnancy. Pubertal timing was measured using a previously validated marker, “the height difference in standard deviations” (HD:SDS), which is the difference between pubertal height and adult height, both in standard deviations. For this study, pubertal height at around 13 years in sons and around 11 years in daughters was obtained from an external database, and adult height was predicted based on parental height reported by mothers. RESULTS: Participation was associated with most exposures but not with pubertal timing, measured by HD:SDS. The associations between exposures and HD:SDS were comparable for participants only and all invited for participation. CONCLUSION: In conclusion, the risk of selection bias in aetiologic studies on pubertal timing in the Puberty Cohort appears minimal.
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spelling pubmed-77541532020-12-23 Risk of selection bias due to non‐participation in a cohort study on pubertal timing Brix, Nis Ernst, Andreas Lauridsen, Lea Lykke Braskhøj Parner, Erik Thorlund Arah, Onyebuchi A. Olsen, Jørn Henriksen, Tine Brink Ramlau‐Hansen, Cecilia Høst Paediatr Perinat Epidemiol Methods BACKGROUND: Non‐participation in aetiologic studies of pubertal timing is frequent. However, little effort has been given to explore the risk and potential impact of selection bias in studies of pubertal timing. OBJECTIVE: We aimed to explore the risk of selection bias due to non‐participation in a newly established puberty cohort. METHODS: We evaluated whether three maternal exposures chosen a priori (pre‐pregnancy obesity, smoking, and alcohol drinking during pregnancy) were associated with participation, whether pubertal timing was associated with participation, and whether selection bias influenced the associations between these exposures and pubertal timing. In total, 22 439 children from the Danish National Birth Cohort born 2000–2003 were invited to the Puberty Cohort and 15 819 (70%) participated. Exposures were self‐reported during pregnancy. Pubertal timing was measured using a previously validated marker, “the height difference in standard deviations” (HD:SDS), which is the difference between pubertal height and adult height, both in standard deviations. For this study, pubertal height at around 13 years in sons and around 11 years in daughters was obtained from an external database, and adult height was predicted based on parental height reported by mothers. RESULTS: Participation was associated with most exposures but not with pubertal timing, measured by HD:SDS. The associations between exposures and HD:SDS were comparable for participants only and all invited for participation. CONCLUSION: In conclusion, the risk of selection bias in aetiologic studies on pubertal timing in the Puberty Cohort appears minimal. John Wiley and Sons Inc. 2020-04-21 2020-11 /pmc/articles/PMC7754153/ /pubmed/32319135 http://dx.doi.org/10.1111/ppe.12679 Text en © 2020 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Methods
Brix, Nis
Ernst, Andreas
Lauridsen, Lea Lykke Braskhøj
Parner, Erik Thorlund
Arah, Onyebuchi A.
Olsen, Jørn
Henriksen, Tine Brink
Ramlau‐Hansen, Cecilia Høst
Risk of selection bias due to non‐participation in a cohort study on pubertal timing
title Risk of selection bias due to non‐participation in a cohort study on pubertal timing
title_full Risk of selection bias due to non‐participation in a cohort study on pubertal timing
title_fullStr Risk of selection bias due to non‐participation in a cohort study on pubertal timing
title_full_unstemmed Risk of selection bias due to non‐participation in a cohort study on pubertal timing
title_short Risk of selection bias due to non‐participation in a cohort study on pubertal timing
title_sort risk of selection bias due to non‐participation in a cohort study on pubertal timing
topic Methods
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754153/
https://www.ncbi.nlm.nih.gov/pubmed/32319135
http://dx.doi.org/10.1111/ppe.12679
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