The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats

OBJECTIVE: The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism. METHODS: Sprague-Dawley (SD) rats (n = 25) were divi...

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Detalles Bibliográficos
Autores principales: Gong, Lei, Wang, Xuyang, Pan, Jinyu, Zhang, Mingjun, Liu, Dian, Liu, Ming, Li, Li, An, Fengshuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754177/
https://www.ncbi.nlm.nih.gov/pubmed/33385063
http://dx.doi.org/10.1515/med-2021-0005

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