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Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs

AIM: Serous carcinoma of the uterine cervix (USCC) is a very rare malignant tumor, while this histological subtype is common in the ovary, fallopian tube, uterine corpus and peritoneum. Because of its rarity, details of the clinicopathological features of USCC are largely unknown. We retrospectively...

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Autores principales: Kitade, Shoko, Ariyoshi, Kazuya, Taguchi, Kenichi, Maenohara, Shoji, Tomita, Yui, Sonoda, Kenzo, Okadome, Masao, Saito, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754289/
https://www.ncbi.nlm.nih.gov/pubmed/31642140
http://dx.doi.org/10.1111/jog.14142
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author Kitade, Shoko
Ariyoshi, Kazuya
Taguchi, Kenichi
Maenohara, Shoji
Tomita, Yui
Sonoda, Kenzo
Okadome, Masao
Saito, Toshiaki
author_facet Kitade, Shoko
Ariyoshi, Kazuya
Taguchi, Kenichi
Maenohara, Shoji
Tomita, Yui
Sonoda, Kenzo
Okadome, Masao
Saito, Toshiaki
author_sort Kitade, Shoko
collection PubMed
description AIM: Serous carcinoma of the uterine cervix (USCC) is a very rare malignant tumor, while this histological subtype is common in the ovary, fallopian tube, uterine corpus and peritoneum. Because of its rarity, details of the clinicopathological features of USCC are largely unknown. We retrospectively analyzed the clinicopathological characteristics of five cases of pure USCC. METHODS: We reviewed the medical records and pathological specimens of five USCC cases who were treated at the Gynecology Service of the National Hospital Organization Kyushu Cancer Center, Japan, between 2000 and 2017. The clinicopathological features were also compared with those of serous carcinomas of the endometrium and ovary who were treated during the same period. RESULTS: Five patients were treated at our hospital between 2000 and 2017. Three tumors were stage IB1, one was stage IIB, and one was stage IVB. The median follow‐up time was 104 months (range 26–210). Four patients other than stage IVB were treated with radical hysterectomy and have been free of relapse. One patient with stage IVB tumor was treated with platinum‐based combination chemotherapy and is currently on maintenance therapy with bevacizumab and remains free of relapse. CONCLUSION: USCC has a distinctive clinicopathological feature that differentiates it from serous carcinomas of other female organs. USCC had been thought to be a poor prognostic disease; however, it could be curable if it is not accompanied by lymph node metastasis or peritoneal dissemination. We might conquer USCC even if it is accompanied by lymph node metastasis with the use of multimodal therapy.
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spelling pubmed-77542892020-12-23 Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs Kitade, Shoko Ariyoshi, Kazuya Taguchi, Kenichi Maenohara, Shoji Tomita, Yui Sonoda, Kenzo Okadome, Masao Saito, Toshiaki J Obstet Gynaecol Res Original Articles AIM: Serous carcinoma of the uterine cervix (USCC) is a very rare malignant tumor, while this histological subtype is common in the ovary, fallopian tube, uterine corpus and peritoneum. Because of its rarity, details of the clinicopathological features of USCC are largely unknown. We retrospectively analyzed the clinicopathological characteristics of five cases of pure USCC. METHODS: We reviewed the medical records and pathological specimens of five USCC cases who were treated at the Gynecology Service of the National Hospital Organization Kyushu Cancer Center, Japan, between 2000 and 2017. The clinicopathological features were also compared with those of serous carcinomas of the endometrium and ovary who were treated during the same period. RESULTS: Five patients were treated at our hospital between 2000 and 2017. Three tumors were stage IB1, one was stage IIB, and one was stage IVB. The median follow‐up time was 104 months (range 26–210). Four patients other than stage IVB were treated with radical hysterectomy and have been free of relapse. One patient with stage IVB tumor was treated with platinum‐based combination chemotherapy and is currently on maintenance therapy with bevacizumab and remains free of relapse. CONCLUSION: USCC has a distinctive clinicopathological feature that differentiates it from serous carcinomas of other female organs. USCC had been thought to be a poor prognostic disease; however, it could be curable if it is not accompanied by lymph node metastasis or peritoneal dissemination. We might conquer USCC even if it is accompanied by lymph node metastasis with the use of multimodal therapy. John Wiley & Sons Australia, Ltd 2019-10-22 2020-01 /pmc/articles/PMC7754289/ /pubmed/31642140 http://dx.doi.org/10.1111/jog.14142 Text en © 2019 The Authors. Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Kitade, Shoko
Ariyoshi, Kazuya
Taguchi, Kenichi
Maenohara, Shoji
Tomita, Yui
Sonoda, Kenzo
Okadome, Masao
Saito, Toshiaki
Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs
title Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs
title_full Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs
title_fullStr Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs
title_full_unstemmed Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs
title_short Serous carcinoma of the uterine cervix: Clinicopathological features differing from serous carcinomas of other female organs
title_sort serous carcinoma of the uterine cervix: clinicopathological features differing from serous carcinomas of other female organs
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754289/
https://www.ncbi.nlm.nih.gov/pubmed/31642140
http://dx.doi.org/10.1111/jog.14142
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