Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire

RAG complexes recognise (cryptic) RSS sites both in and outside immunoglobulin sites. Excision circles may be reinserted into V(D)J rearrangements as long templated insertions to diversify the adaptive immune repertoire. We show that such VDJ with templated insertions are incidentally found in the r...

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Detalles Bibliográficos
Autores principales: Koning, Marvyn T., Vletter, Esther M., Rademaker, Rik, Vergroesen, Rochelle D., Trollmann, Ignis J.M., Parren, Paul, van Bergen, Cornelis A.M., Scherer, Hans U., Kiełbasa, Szymon M., Toes, René E.M., Veelken, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754338/
https://www.ncbi.nlm.nih.gov/pubmed/32762049
http://dx.doi.org/10.1002/eji.202048828
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author Koning, Marvyn T.
Vletter, Esther M.
Rademaker, Rik
Vergroesen, Rochelle D.
Trollmann, Ignis J.M.
Parren, Paul
van Bergen, Cornelis A.M.
Scherer, Hans U.
Kiełbasa, Szymon M.
Toes, René E.M.
Veelken, Hendrik
author_facet Koning, Marvyn T.
Vletter, Esther M.
Rademaker, Rik
Vergroesen, Rochelle D.
Trollmann, Ignis J.M.
Parren, Paul
van Bergen, Cornelis A.M.
Scherer, Hans U.
Kiełbasa, Szymon M.
Toes, René E.M.
Veelken, Hendrik
author_sort Koning, Marvyn T.
collection PubMed
description RAG complexes recognise (cryptic) RSS sites both in and outside immunoglobulin sites. Excision circles may be reinserted into V(D)J rearrangements as long templated insertions to diversify the adaptive immune repertoire. We show that such VDJ with templated insertions are incidentally found in the repertoire of healthy donors. [Image: see text]
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spelling pubmed-77543382020-12-23 Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire Koning, Marvyn T. Vletter, Esther M. Rademaker, Rik Vergroesen, Rochelle D. Trollmann, Ignis J.M. Parren, Paul van Bergen, Cornelis A.M. Scherer, Hans U. Kiełbasa, Szymon M. Toes, René E.M. Veelken, Hendrik Eur J Immunol Letters to the Editor RAG complexes recognise (cryptic) RSS sites both in and outside immunoglobulin sites. Excision circles may be reinserted into V(D)J rearrangements as long templated insertions to diversify the adaptive immune repertoire. We show that such VDJ with templated insertions are incidentally found in the repertoire of healthy donors. [Image: see text] John Wiley and Sons Inc. 2020-08-27 2020-12 /pmc/articles/PMC7754338/ /pubmed/32762049 http://dx.doi.org/10.1002/eji.202048828 Text en © 2020 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letters to the Editor
Koning, Marvyn T.
Vletter, Esther M.
Rademaker, Rik
Vergroesen, Rochelle D.
Trollmann, Ignis J.M.
Parren, Paul
van Bergen, Cornelis A.M.
Scherer, Hans U.
Kiełbasa, Szymon M.
Toes, René E.M.
Veelken, Hendrik
Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire
title Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire
title_full Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire
title_fullStr Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire
title_full_unstemmed Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire
title_short Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire
title_sort templated insertions at vd and dj junctions create unique b‐cell receptors in the healthy b‐cell repertoire
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754338/
https://www.ncbi.nlm.nih.gov/pubmed/32762049
http://dx.doi.org/10.1002/eji.202048828
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