Templated insertions at VD and DJ junctions create unique B‐cell receptors in the healthy B‐cell repertoire

RAG complexes recognise (cryptic) RSS sites both in and outside immunoglobulin sites. Excision circles may be reinserted into V(D)J rearrangements as long templated insertions to diversify the adaptive immune repertoire. We show that such VDJ with templated insertions are incidentally found in the r...

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Detalles Bibliográficos
Autores principales: Koning, Marvyn T., Vletter, Esther M., Rademaker, Rik, Vergroesen, Rochelle D., Trollmann, Ignis J.M., Parren, Paul, van Bergen, Cornelis A.M., Scherer, Hans U., Kiełbasa, Szymon M., Toes, René E.M., Veelken, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754338/
https://www.ncbi.nlm.nih.gov/pubmed/32762049
http://dx.doi.org/10.1002/eji.202048828

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