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Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study
BACKGROUND: Impaired gastric emptying (GE) is associated with morbidity in surgical critically ill children. The relationship between inflammation, gut barrier integrity (lipopolysaccharide binding protein [LBP]; zonulin), and GE has not been described in this cohort. METHODS: Children ≥2 years of a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754495/ https://www.ncbi.nlm.nih.gov/pubmed/32386238 http://dx.doi.org/10.1002/jpen.1874 |
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author | Martinez, Enid E. Zurakowski, David Pereira, Luis Freire, Rachel Emans, John B. Nurko, Samuel Duggan, Christopher P. Fasano, Alessio Mehta, Nilesh M. |
author_facet | Martinez, Enid E. Zurakowski, David Pereira, Luis Freire, Rachel Emans, John B. Nurko, Samuel Duggan, Christopher P. Fasano, Alessio Mehta, Nilesh M. |
author_sort | Martinez, Enid E. |
collection | PubMed |
description | BACKGROUND: Impaired gastric emptying (GE) is associated with morbidity in surgical critically ill children. The relationship between inflammation, gut barrier integrity (lipopolysaccharide binding protein [LBP]; zonulin), and GE has not been described in this cohort. METHODS: Children ≥2 years of age and requiring critical care after surgery were enrolled. Preoperative and postoperative levels of serum cytokines, LBP, and zonulin, and GE by the acetaminophen absorption test, were measured, allowing patients to serve as their own controls. Postoperative delayed GE was defined as a decrease in GE by ≥20% compared with preoperative GE. The following were examined : comparison between postoperative andpreoperative values, correlations between fold change (postoperative/preoperative) in study variables, and fold change in study variables between patients with and without postoperative delayed GE. RESULTS: Twenty patients, median age 14 years (12.25, 18), 12 female, were included. Eight of 20 patients had postoperative delayed GE. Postoperative interleukin‐6 (IL‐6), IL‐8, IL‐10, and LBP were increased, and zonulin was decreased (P‐values < .05). Fold change in IL‐10 and zonulin were inversely correlated (ρ −0.618, P = .004). Patients with postoperative delayed GE had greater fold increase in IL‐10 (P = .0159) and fold decrease in zonulin (P = .0160). Five of 7 (71%) patients with both fold increase in IL‐10 and decrease in zonulin had delayed GE. CONCLUSION: Postoperative changes in IL‐10 and zonulin were associated with delayed GE in surgical critically ill children, which might suggest a mechanism to for delayed GE in postoperative inflammation and gut barrier dysregulation after surgery. |
format | Online Article Text |
id | pubmed-7754495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77544952020-12-28 Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study Martinez, Enid E. Zurakowski, David Pereira, Luis Freire, Rachel Emans, John B. Nurko, Samuel Duggan, Christopher P. Fasano, Alessio Mehta, Nilesh M. JPEN J Parenter Enteral Nutr Premier Research Papers BACKGROUND: Impaired gastric emptying (GE) is associated with morbidity in surgical critically ill children. The relationship between inflammation, gut barrier integrity (lipopolysaccharide binding protein [LBP]; zonulin), and GE has not been described in this cohort. METHODS: Children ≥2 years of age and requiring critical care after surgery were enrolled. Preoperative and postoperative levels of serum cytokines, LBP, and zonulin, and GE by the acetaminophen absorption test, were measured, allowing patients to serve as their own controls. Postoperative delayed GE was defined as a decrease in GE by ≥20% compared with preoperative GE. The following were examined : comparison between postoperative andpreoperative values, correlations between fold change (postoperative/preoperative) in study variables, and fold change in study variables between patients with and without postoperative delayed GE. RESULTS: Twenty patients, median age 14 years (12.25, 18), 12 female, were included. Eight of 20 patients had postoperative delayed GE. Postoperative interleukin‐6 (IL‐6), IL‐8, IL‐10, and LBP were increased, and zonulin was decreased (P‐values < .05). Fold change in IL‐10 and zonulin were inversely correlated (ρ −0.618, P = .004). Patients with postoperative delayed GE had greater fold increase in IL‐10 (P = .0159) and fold decrease in zonulin (P = .0160). Five of 7 (71%) patients with both fold increase in IL‐10 and decrease in zonulin had delayed GE. CONCLUSION: Postoperative changes in IL‐10 and zonulin were associated with delayed GE in surgical critically ill children, which might suggest a mechanism to for delayed GE in postoperative inflammation and gut barrier dysregulation after surgery. John Wiley and Sons Inc. 2020-06-03 2020-11 /pmc/articles/PMC7754495/ /pubmed/32386238 http://dx.doi.org/10.1002/jpen.1874 Text en © 2020 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Premier Research Papers Martinez, Enid E. Zurakowski, David Pereira, Luis Freire, Rachel Emans, John B. Nurko, Samuel Duggan, Christopher P. Fasano, Alessio Mehta, Nilesh M. Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study |
title | Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study |
title_full | Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study |
title_fullStr | Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study |
title_full_unstemmed | Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study |
title_short | Interleukin‐10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study |
title_sort | interleukin‐10 and zonulin are associated with postoperative delayed gastric emptying in critically ill surgical pediatric patients: a prospective pilot study |
topic | Premier Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754495/ https://www.ncbi.nlm.nih.gov/pubmed/32386238 http://dx.doi.org/10.1002/jpen.1874 |
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