Lipid metabolism and cancer

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor micr...

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Detalles Bibliográficos
Autores principales: Bian, Xueli, Liu, Rui, Meng, Ying, Xing, Dongming, Xu, Daqian, Lu, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754673/
https://www.ncbi.nlm.nih.gov/pubmed/33601415
http://dx.doi.org/10.1084/jem.20201606
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author Bian, Xueli
Liu, Rui
Meng, Ying
Xing, Dongming
Xu, Daqian
Lu, Zhimin
author_facet Bian, Xueli
Liu, Rui
Meng, Ying
Xing, Dongming
Xu, Daqian
Lu, Zhimin
author_sort Bian, Xueli
collection PubMed
description Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy.
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spelling pubmed-77546732021-07-04 Lipid metabolism and cancer Bian, Xueli Liu, Rui Meng, Ying Xing, Dongming Xu, Daqian Lu, Zhimin J Exp Med Review Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy. Rockefeller University Press 2020-12-18 /pmc/articles/PMC7754673/ /pubmed/33601415 http://dx.doi.org/10.1084/jem.20201606 Text en © 2020 Bian et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Review
Bian, Xueli
Liu, Rui
Meng, Ying
Xing, Dongming
Xu, Daqian
Lu, Zhimin
Lipid metabolism and cancer
title Lipid metabolism and cancer
title_full Lipid metabolism and cancer
title_fullStr Lipid metabolism and cancer
title_full_unstemmed Lipid metabolism and cancer
title_short Lipid metabolism and cancer
title_sort lipid metabolism and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754673/
https://www.ncbi.nlm.nih.gov/pubmed/33601415
http://dx.doi.org/10.1084/jem.20201606
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