The relationship between coronary artery disease and SIRT1 protein

Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD. SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms. SIRT1 has roles in regulating angiogenesis and preven...

Descripción completa

Detalles Bibliográficos
Autores principales: Askin, Lutfu, Tibilli, Hakan, Tanriverdi, Okan, Turkmen, Serdar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754863/
https://www.ncbi.nlm.nih.gov/pubmed/33381707
http://dx.doi.org/10.14744/nci.2020.31391
_version_ 1783626266740523008
author Askin, Lutfu
Tibilli, Hakan
Tanriverdi, Okan
Turkmen, Serdar
author_facet Askin, Lutfu
Tibilli, Hakan
Tanriverdi, Okan
Turkmen, Serdar
author_sort Askin, Lutfu
collection PubMed
description Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD. SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms. SIRT1 has roles in regulating angiogenesis and preventing endothelial dysfunction and reperfusion injury due to ischemia. Suppression of SIRT1 causes monocyte affinity due to endothelial dysfunction. Sirtuins activators are involved in pathologies of many diseases with promising treatments. The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD.
format Online
Article
Text
id pubmed-7754863
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Kare Publishing
record_format MEDLINE/PubMed
spelling pubmed-77548632020-12-29 The relationship between coronary artery disease and SIRT1 protein Askin, Lutfu Tibilli, Hakan Tanriverdi, Okan Turkmen, Serdar North Clin Istanb Review Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD. SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms. SIRT1 has roles in regulating angiogenesis and preventing endothelial dysfunction and reperfusion injury due to ischemia. Suppression of SIRT1 causes monocyte affinity due to endothelial dysfunction. Sirtuins activators are involved in pathologies of many diseases with promising treatments. The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD. Kare Publishing 2020-10-01 /pmc/articles/PMC7754863/ /pubmed/33381707 http://dx.doi.org/10.14744/nci.2020.31391 Text en Copyright: © 2020 by Istanbul Northern Anatolian Association of Public Hospitals http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Review
Askin, Lutfu
Tibilli, Hakan
Tanriverdi, Okan
Turkmen, Serdar
The relationship between coronary artery disease and SIRT1 protein
title The relationship between coronary artery disease and SIRT1 protein
title_full The relationship between coronary artery disease and SIRT1 protein
title_fullStr The relationship between coronary artery disease and SIRT1 protein
title_full_unstemmed The relationship between coronary artery disease and SIRT1 protein
title_short The relationship between coronary artery disease and SIRT1 protein
title_sort relationship between coronary artery disease and sirt1 protein
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754863/
https://www.ncbi.nlm.nih.gov/pubmed/33381707
http://dx.doi.org/10.14744/nci.2020.31391
work_keys_str_mv AT askinlutfu therelationshipbetweencoronaryarterydiseaseandsirt1protein
AT tibillihakan therelationshipbetweencoronaryarterydiseaseandsirt1protein
AT tanriverdiokan therelationshipbetweencoronaryarterydiseaseandsirt1protein
AT turkmenserdar therelationshipbetweencoronaryarterydiseaseandsirt1protein
AT askinlutfu relationshipbetweencoronaryarterydiseaseandsirt1protein
AT tibillihakan relationshipbetweencoronaryarterydiseaseandsirt1protein
AT tanriverdiokan relationshipbetweencoronaryarterydiseaseandsirt1protein
AT turkmenserdar relationshipbetweencoronaryarterydiseaseandsirt1protein

Ejemplares similares