The role of NO in COVID-19 and potential therapeutic strategies

Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation...

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Detalles Bibliográficos
Autores principales: Fang, Wanyi, Jiang, Jingrui, Su, Lei, Shu, Tong, Liu, Huan, Lai, Shenghan, Ghiladi, Reza A., Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754882/
https://www.ncbi.nlm.nih.gov/pubmed/33347987
http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.008
Descripción
Sumario:Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19.

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