The role of NO in COVID-19 and potential therapeutic strategies

Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation...

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Autores principales: Fang, Wanyi, Jiang, Jingrui, Su, Lei, Shu, Tong, Liu, Huan, Lai, Shenghan, Ghiladi, Reza A., Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754882/
https://www.ncbi.nlm.nih.gov/pubmed/33347987
http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.008
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author Fang, Wanyi
Jiang, Jingrui
Su, Lei
Shu, Tong
Liu, Huan
Lai, Shenghan
Ghiladi, Reza A.
Wang, Jun
author_facet Fang, Wanyi
Jiang, Jingrui
Su, Lei
Shu, Tong
Liu, Huan
Lai, Shenghan
Ghiladi, Reza A.
Wang, Jun
author_sort Fang, Wanyi
collection PubMed
description Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19.
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spelling pubmed-77548822020-12-22 The role of NO in COVID-19 and potential therapeutic strategies Fang, Wanyi Jiang, Jingrui Su, Lei Shu, Tong Liu, Huan Lai, Shenghan Ghiladi, Reza A. Wang, Jun Free Radic Biol Med Review Article Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19. Elsevier Inc. 2021-02-01 2020-12-22 /pmc/articles/PMC7754882/ /pubmed/33347987 http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.008 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Fang, Wanyi
Jiang, Jingrui
Su, Lei
Shu, Tong
Liu, Huan
Lai, Shenghan
Ghiladi, Reza A.
Wang, Jun
The role of NO in COVID-19 and potential therapeutic strategies
title The role of NO in COVID-19 and potential therapeutic strategies
title_full The role of NO in COVID-19 and potential therapeutic strategies
title_fullStr The role of NO in COVID-19 and potential therapeutic strategies
title_full_unstemmed The role of NO in COVID-19 and potential therapeutic strategies
title_short The role of NO in COVID-19 and potential therapeutic strategies
title_sort role of no in covid-19 and potential therapeutic strategies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754882/
https://www.ncbi.nlm.nih.gov/pubmed/33347987
http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.008
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