Cargando…

Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice

Recent studies have shown the potential of broadly neutralizing antibodies (bnAbs) for HIV-1 treatment. One of the candidate antibodies moving into clinical trials is the bnAb PGDM1400. Here, we studied the therapeutic potency and escape pathways of bnAb PGDM1400 during monovalent therapy in human i...

Descripción completa

Detalles Bibliográficos
Autores principales:	van der Velden, Yme U., Villaudy, Julien, Siteur - van Rijnstra, Esther, van der Linden, Cynthia A., Vink, Monique A., Schermer, Edith E., Weijer, Kees, Berkhout, Ben, Sanders, Rogier W., van Gils, Marit J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755169/ https://www.ncbi.nlm.nih.gov/pubmed/33218286 http://dx.doi.org/10.1080/19420862.2020.1845908

Ejemplares similares

Early Effects of HTLV-1 Infection on the Activation, Exhaustion, and Differentiation of T-Cells in Humanized NSG Mice
por: Espíndola, Otávio de Melo, et al.
Publicado: (2021)

A SARS-CoV-2 Wuhan spike virosome vaccine induces superior neutralization breadth compared to one using the Beta spike
por: van der Velden, Yme U., et al.
Publicado: (2022)

Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS
por: Wesley, Martina S., et al.
Publicado: (2021)

ABX464: a good drug candidate instead of a magic bullet
por: Berkhout, Ben, et al.
Publicado: (2015)

Engineered miniature H1 promoters with dedicated RNA polymerase II or III activity
por: Gao, Zongliang, et al.
Publicado: (2020)

Preclinical In Vivo Evaluation of the Safety of a Multi-shRNA-based Gene Therapy Against HIV-1
por: Centlivre, Mireille, et al.
Publicado: (2013)

HIV-1 tolerates changes in A-count in a small segment of the pol gene
por: Klaver, Bep, et al.
Publicado: (2017)

A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
por: Brinkkemper, Mitch, et al.
Publicado: (2021)

The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome
por: van Bel, Nikki, et al.
Publicado: (2014)

Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses
por: Brinkkemper, Mitch, et al.
Publicado: (2022)

Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in
por: van der Velden, Yme U., et al.
Publicado: (2011)

Development of Monoclonal Antibody-Based EIA for Tetranor-PGDM which Reflects PGD(2) Production in the Body
por: Nagata, Nanae, et al.
Publicado: (2021)

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody
por: Schommers, Philipp, et al.
Publicado: (2020)

The Polycomb Group Protein Ring1b/Rnf2 Is Specifically Required for Craniofacial Development
por: van der Velden, Yme U., et al.
Publicado: (2013)

Editorial: Novel Concepts in Using Broadly Neutralizing Antibodies for HIV-1 Treatment and Prevention
por: Wagh, Kshitij, et al.
Publicado: (2021)

Health and disease as practical concepts: exploring function in context-specific definitions
por: van der Linden, Rik, et al.
Publicado: (2021)

Europa 1400 : la crisis de la baja Edad Media
Publicado: (1993)

Arquitectura en Italia,1400-1600
por: Heydenreich, Ludwig H.
Publicado: (2007)

English medieval theatre, 1400-1500 /
por: Tydeman, William
Publicado: (1986)

Arquitectura en Italia,1400-1600
por: Heydenreich, Ludwig H.
Publicado: (1991)

Capitalism and material life 1400–1800
Publicado: (1977)

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users
por: EULER, Zelda, et al.
Publicado: (2019)

Regulatory role of upstream AUG codons within the SIVmac239 genome
por: van der Velden, Gisela J, et al.
Publicado: (2011)

HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds
por: van den Kerkhof, Tom L. G. M., et al.
Publicado: (2016)

Music in the French secular theater, 1400-1550
por: Brown, Howard Mayer
Publicado: (1963)

The surgeoness: the female practitioner of surgery 1400-1800.
por: Wyman, A L
Publicado: (1984)

Names of body parts in English, 1400–1550
por: French, Roger
Publicado: (2001)

Some Notes on 1,400 Cases of Anæsthesia
por: Allardice, Wm. C.
Publicado: (1896)

HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome
por: Westerhout, Ellen M., et al.
Publicado: (2005)

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
por: Brouwer, Philip J.M., et al.
Publicado: (2021)

Handbook of European history, 1400-1600 : late Middle Ages, Renaissance, and Reformation /

Geometrical objects: architecture and the mathematical sciences 1400-1800
por: Gerbino, Anthony
Publicado: (2014)

Arte y arquitectura en Italia, 1250-1400 /
por: White, John, 1924-
Publicado: (1989)

Africa and africans in the making of the atlantic world, 1400-1800 /
por: Thornton, John K. (John Kelly), 1949-
Publicado: (1998)

Spin, isospin and decay rates of $\overline{K}$ * (1400)
por: Badier, J, et al.
Publicado: (1965)

Medieval foundations of the western intellectual tradition, 400-1400 /
por: Colish, Marcia L.

Metamaterial emitter for thermophotovoltaics stable up to 1400 °C
por: Chirumamilla, Manohar, et al.
Publicado: (2019)

Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia
por: van Gils, Noortje, et al.
Publicado: (2021)

Rhinosinusitis in morbidity registrations in Dutch General Practice: a retro-spective case-control study
por: Hoffmans, Ruth, et al.
Publicado: (2015)

The art of medicine. medical teaching at the University of Paris, 1250–1400
por: Biller, Peter
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_jkd3bkkblij0ui3j7rir6pqsf4