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The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study

The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (me...

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Autores principales: Wang, Yu, Liang, Hongyuan, Zhang, Ling, Zhang, Zhe, Wu, Liang, Ni, Liang, Gao, Guiju, Yang, Di, Zhao, Hongxin, Xiao, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755215/
https://www.ncbi.nlm.nih.gov/pubmed/33351812
http://dx.doi.org/10.1371/journal.pone.0243773
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author Wang, Yu
Liang, Hongyuan
Zhang, Ling
Zhang, Zhe
Wu, Liang
Ni, Liang
Gao, Guiju
Yang, Di
Zhao, Hongxin
Xiao, Jiang
author_facet Wang, Yu
Liang, Hongyuan
Zhang, Ling
Zhang, Zhe
Wu, Liang
Ni, Liang
Gao, Guiju
Yang, Di
Zhao, Hongxin
Xiao, Jiang
author_sort Wang, Yu
collection PubMed
description The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (median age: 38.2 years, range: 18–78 years) admitted in Beijing Ditan Hospital between January 2009 and December 2018. Among 1309 patients, 143 patients (10.9%) had at least one serious NADEs, including 49 (3.8%) with cerebrovascular diseases, 37 (2.8%) with non-AIDS-defining cancers, 28 (2.1%) with chronic kidney diseases, 26 (2.0%) with cardiovascular diseases, and 18 (1.4%) with liver cirrhosis. Serious NADEs distributed in different age and CD4 levels, especially with age ≥50 years and CD4 ≤350 cells/ul. Other traditional risk factors, including cigarette smoking (OR = 1.9, 95%CI = 1.3–2.8, p = 0.002), hypertension (OR = 2.5, 95%CI = 1.7–3.7, p<0.001), chronic HCV infection (OR = 2.8, 95%CI = 1.4–5.6, p = 0.004), and hypercholesterolemia (OR = 4.1, 95% CI = 1.2–14.1, p = 0.026), were also associated with serious NADEs. Seventeen cases (1.3%) with serious NADEs died among hospitalized cART-naive AIDS patients, and severe pneumonia (HR = 5.5, 95%CI = 1.9–15.9, p<0.001) and AIDS-defining cancers (HR = 3.8, 95%CI = 1.1–13.2, p = 0.038) were identified as risk factors associated with an increased hazard of mortality among these patients with serious NADEs. Serious NADEs also occurred in cART-naive AIDS patients in China with low prevalence. Our results reminded physicians that early screening of serious NADEs, timely intervention of their risk factors, management of severe AIDS-defining events, multi-disciplinary cooperation, and early initiation of cART were essential to reduce the burden of serious NADEs.
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spelling pubmed-77552152021-01-05 The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study Wang, Yu Liang, Hongyuan Zhang, Ling Zhang, Zhe Wu, Liang Ni, Liang Gao, Guiju Yang, Di Zhao, Hongxin Xiao, Jiang PLoS One Research Article The objective of this study was to elucidate the burden, risk factors, and prognosis of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China. The evaluation of the burden, risk factors and prognosis of serious NADEs was carried out among 1309 cART-naive AIDS patients (median age: 38.2 years, range: 18–78 years) admitted in Beijing Ditan Hospital between January 2009 and December 2018. Among 1309 patients, 143 patients (10.9%) had at least one serious NADEs, including 49 (3.8%) with cerebrovascular diseases, 37 (2.8%) with non-AIDS-defining cancers, 28 (2.1%) with chronic kidney diseases, 26 (2.0%) with cardiovascular diseases, and 18 (1.4%) with liver cirrhosis. Serious NADEs distributed in different age and CD4 levels, especially with age ≥50 years and CD4 ≤350 cells/ul. Other traditional risk factors, including cigarette smoking (OR = 1.9, 95%CI = 1.3–2.8, p = 0.002), hypertension (OR = 2.5, 95%CI = 1.7–3.7, p<0.001), chronic HCV infection (OR = 2.8, 95%CI = 1.4–5.6, p = 0.004), and hypercholesterolemia (OR = 4.1, 95% CI = 1.2–14.1, p = 0.026), were also associated with serious NADEs. Seventeen cases (1.3%) with serious NADEs died among hospitalized cART-naive AIDS patients, and severe pneumonia (HR = 5.5, 95%CI = 1.9–15.9, p<0.001) and AIDS-defining cancers (HR = 3.8, 95%CI = 1.1–13.2, p = 0.038) were identified as risk factors associated with an increased hazard of mortality among these patients with serious NADEs. Serious NADEs also occurred in cART-naive AIDS patients in China with low prevalence. Our results reminded physicians that early screening of serious NADEs, timely intervention of their risk factors, management of severe AIDS-defining events, multi-disciplinary cooperation, and early initiation of cART were essential to reduce the burden of serious NADEs. Public Library of Science 2020-12-22 /pmc/articles/PMC7755215/ /pubmed/33351812 http://dx.doi.org/10.1371/journal.pone.0243773 Text en © 2020 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wang, Yu
Liang, Hongyuan
Zhang, Ling
Zhang, Zhe
Wu, Liang
Ni, Liang
Gao, Guiju
Yang, Di
Zhao, Hongxin
Xiao, Jiang
The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study
title The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study
title_full The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study
title_fullStr The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study
title_full_unstemmed The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study
title_short The burden of serious non-AIDS-defining events among admitted cART-naive AIDS patients in China: An observational cohort study
title_sort burden of serious non-aids-defining events among admitted cart-naive aids patients in china: an observational cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755215/
https://www.ncbi.nlm.nih.gov/pubmed/33351812
http://dx.doi.org/10.1371/journal.pone.0243773
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