TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage

TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes neurons to double strand DNA breaks (DSBs). Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder, in which 97% of...

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Detalles Bibliográficos
Autores principales: Giannini, Marta, Bayona-Feliu, Aleix, Sproviero, Daisy, Barroso, Sonia I., Cereda, Cristina, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755276/
https://www.ncbi.nlm.nih.gov/pubmed/33301444
http://dx.doi.org/10.1371/journal.pgen.1009260

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