MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice

Given its glycemic efficacy and ability to reduce the body weight, glucagon-like peptide 1 receptor (GLP-1R) agonism has emerged as a preferred treatment for diabetes associated with obesity. We here report that a small-molecule Class 1 histone deacetylase (HDAC) inhibitor Entinostat (MS-275) enhanc...

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Detalles Bibliográficos
Autores principales: Bele, Shilpak, Girada, Shravan Babu, Ray, Aramita, Gupta, Abhishek, Oruganti, Srinivas, Prakash Babu, Phanithi, Rayalla, Rahul SR, Kalivendi, Shashi Vardhan, Ibrahim, Ahamed, Puri, Vishwajeet, Adalla, Venkateswar, Katika, Madhumohan R, DiMarchi, Richard, Mitra, Prasenjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755393/
https://www.ncbi.nlm.nih.gov/pubmed/33349332
http://dx.doi.org/10.7554/eLife.52212

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