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Sleep Deprivation and Neurological Disorders

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurot...

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Autores principales: Bishir, Muhammed, Bhat, Abid, Essa, Musthafa Mohamed, Ekpo, Okobi, Ihunwo, Amadi O., Veeraraghavan, Vishnu Priya, Mohan, Surapaneni Krishna, Mahalakshmi, Arehally M., Ray, Bipul, Tuladhar, Sunanda, Chang, Sulie, Chidambaram, Saravana Babu, Sakharkar, Meena Kishore, Guillemin, Gilles J., Qoronfleh, M. Walid, Ojcius, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755475/
https://www.ncbi.nlm.nih.gov/pubmed/33381558
http://dx.doi.org/10.1155/2020/5764017
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author Bishir, Muhammed
Bhat, Abid
Essa, Musthafa Mohamed
Ekpo, Okobi
Ihunwo, Amadi O.
Veeraraghavan, Vishnu Priya
Mohan, Surapaneni Krishna
Mahalakshmi, Arehally M.
Ray, Bipul
Tuladhar, Sunanda
Chang, Sulie
Chidambaram, Saravana Babu
Sakharkar, Meena Kishore
Guillemin, Gilles J.
Qoronfleh, M. Walid
Ojcius, David M.
author_facet Bishir, Muhammed
Bhat, Abid
Essa, Musthafa Mohamed
Ekpo, Okobi
Ihunwo, Amadi O.
Veeraraghavan, Vishnu Priya
Mohan, Surapaneni Krishna
Mahalakshmi, Arehally M.
Ray, Bipul
Tuladhar, Sunanda
Chang, Sulie
Chidambaram, Saravana Babu
Sakharkar, Meena Kishore
Guillemin, Gilles J.
Qoronfleh, M. Walid
Ojcius, David M.
author_sort Bishir, Muhammed
collection PubMed
description Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, and tau which are involved in major neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended.
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spelling pubmed-77554752020-12-29 Sleep Deprivation and Neurological Disorders Bishir, Muhammed Bhat, Abid Essa, Musthafa Mohamed Ekpo, Okobi Ihunwo, Amadi O. Veeraraghavan, Vishnu Priya Mohan, Surapaneni Krishna Mahalakshmi, Arehally M. Ray, Bipul Tuladhar, Sunanda Chang, Sulie Chidambaram, Saravana Babu Sakharkar, Meena Kishore Guillemin, Gilles J. Qoronfleh, M. Walid Ojcius, David M. Biomed Res Int Review Article Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, and tau which are involved in major neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended. Hindawi 2020-11-23 /pmc/articles/PMC7755475/ /pubmed/33381558 http://dx.doi.org/10.1155/2020/5764017 Text en Copyright © 2020 Muhammed Bishir et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bishir, Muhammed
Bhat, Abid
Essa, Musthafa Mohamed
Ekpo, Okobi
Ihunwo, Amadi O.
Veeraraghavan, Vishnu Priya
Mohan, Surapaneni Krishna
Mahalakshmi, Arehally M.
Ray, Bipul
Tuladhar, Sunanda
Chang, Sulie
Chidambaram, Saravana Babu
Sakharkar, Meena Kishore
Guillemin, Gilles J.
Qoronfleh, M. Walid
Ojcius, David M.
Sleep Deprivation and Neurological Disorders
title Sleep Deprivation and Neurological Disorders
title_full Sleep Deprivation and Neurological Disorders
title_fullStr Sleep Deprivation and Neurological Disorders
title_full_unstemmed Sleep Deprivation and Neurological Disorders
title_short Sleep Deprivation and Neurological Disorders
title_sort sleep deprivation and neurological disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755475/
https://www.ncbi.nlm.nih.gov/pubmed/33381558
http://dx.doi.org/10.1155/2020/5764017
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