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Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall

Chronic venous disease (CVeD) has a remarkable prevalence, with an estimated annual incidence of 2%. It has been demonstrated how the loss of homeostatic mechanisms in the vein wall can take part in the physiopathology of CVeD. In this regard, it has been described how different axis, such as IGF-1/...

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Autores principales: Ortega, Miguel A., Fraile-Martínez, Oscar, Asúnsolo, Ángel, Martínez-Vivero, Clara, Pekarek, Leonel, Coca, Santiago, Guijarro, Luis G., Álvarez-Mon, Melchor, Buján, Julia, García-Honduvilla, Natalio, Sainz, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755481/
https://www.ncbi.nlm.nih.gov/pubmed/33381575
http://dx.doi.org/10.1155/2020/6782659
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author Ortega, Miguel A.
Fraile-Martínez, Oscar
Asúnsolo, Ángel
Martínez-Vivero, Clara
Pekarek, Leonel
Coca, Santiago
Guijarro, Luis G.
Álvarez-Mon, Melchor
Buján, Julia
García-Honduvilla, Natalio
Sainz, Felipe
author_facet Ortega, Miguel A.
Fraile-Martínez, Oscar
Asúnsolo, Ángel
Martínez-Vivero, Clara
Pekarek, Leonel
Coca, Santiago
Guijarro, Luis G.
Álvarez-Mon, Melchor
Buján, Julia
García-Honduvilla, Natalio
Sainz, Felipe
author_sort Ortega, Miguel A.
collection PubMed
description Chronic venous disease (CVeD) has a remarkable prevalence, with an estimated annual incidence of 2%. It has been demonstrated how the loss of homeostatic mechanisms in the vein wall can take part in the physiopathology of CVeD. In this regard, it has been described how different axis, such as IGF-1/PAPP-A/STC-2 axis, may play an essential role in tissue homeostasis. The aim of this research is to study both genetic and protein expressions of the IGF-1/PAPP-A/STC-2 axis in CVeD patients. It is a cross-sectional study in which genetic (RT-qPCR) and protein (immunohistochemistry) expression analysis techniques were accomplished in saphenous veins from CVeD patients (n = 35) in comparison to individuals without vascular pathology (HV). Results show a significant increase in both genetic and protein expressions of PAPP-A and IGF-1, and a decrement STC-2 expression at the same time in CVeD patients. Our study is a pioneer for demonstrating that the expression of the different components of the IGF-1/PAPP-A/STC-2 axis is altered in CVeD patients. This fact can be a part of the loss of homeostatic mechanisms of the venous tissue. Further research should be destined to deepen into alterations of this axis, as well as to evaluate the usage of these components as therapeutic targets for CVeD.
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spelling pubmed-77554812020-12-29 Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall Ortega, Miguel A. Fraile-Martínez, Oscar Asúnsolo, Ángel Martínez-Vivero, Clara Pekarek, Leonel Coca, Santiago Guijarro, Luis G. Álvarez-Mon, Melchor Buján, Julia García-Honduvilla, Natalio Sainz, Felipe Biomed Res Int Research Article Chronic venous disease (CVeD) has a remarkable prevalence, with an estimated annual incidence of 2%. It has been demonstrated how the loss of homeostatic mechanisms in the vein wall can take part in the physiopathology of CVeD. In this regard, it has been described how different axis, such as IGF-1/PAPP-A/STC-2 axis, may play an essential role in tissue homeostasis. The aim of this research is to study both genetic and protein expressions of the IGF-1/PAPP-A/STC-2 axis in CVeD patients. It is a cross-sectional study in which genetic (RT-qPCR) and protein (immunohistochemistry) expression analysis techniques were accomplished in saphenous veins from CVeD patients (n = 35) in comparison to individuals without vascular pathology (HV). Results show a significant increase in both genetic and protein expressions of PAPP-A and IGF-1, and a decrement STC-2 expression at the same time in CVeD patients. Our study is a pioneer for demonstrating that the expression of the different components of the IGF-1/PAPP-A/STC-2 axis is altered in CVeD patients. This fact can be a part of the loss of homeostatic mechanisms of the venous tissue. Further research should be destined to deepen into alterations of this axis, as well as to evaluate the usage of these components as therapeutic targets for CVeD. Hindawi 2020-12-14 /pmc/articles/PMC7755481/ /pubmed/33381575 http://dx.doi.org/10.1155/2020/6782659 Text en Copyright © 2020 Miguel A. Ortega et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ortega, Miguel A.
Fraile-Martínez, Oscar
Asúnsolo, Ángel
Martínez-Vivero, Clara
Pekarek, Leonel
Coca, Santiago
Guijarro, Luis G.
Álvarez-Mon, Melchor
Buján, Julia
García-Honduvilla, Natalio
Sainz, Felipe
Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall
title Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall
title_full Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall
title_fullStr Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall
title_full_unstemmed Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall
title_short Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall
title_sort chronic venous disease patients showed altered expression of igf-1/papp-a/stc-2 axis in the vein wall
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755481/
https://www.ncbi.nlm.nih.gov/pubmed/33381575
http://dx.doi.org/10.1155/2020/6782659
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