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Biologically active compounds from marine organisms in the strategies for combating coronaviruses

Despite the progress made in immunization and drug development, so far there are no prophylactic vaccines and effective therapies for many viral infections, including infections caused by coronaviruses. In this regard, the search for new antiviral substances continues to be relevant, and the enormou...

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Autores principales: Zaporozhets, Tatyana S., Besednova, Nataliya N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755586/
https://www.ncbi.nlm.nih.gov/pubmed/33364539
http://dx.doi.org/10.3934/microbiol.2020028
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author Zaporozhets, Tatyana S.
Besednova, Nataliya N.
author_facet Zaporozhets, Tatyana S.
Besednova, Nataliya N.
author_sort Zaporozhets, Tatyana S.
collection PubMed
description Despite the progress made in immunization and drug development, so far there are no prophylactic vaccines and effective therapies for many viral infections, including infections caused by coronaviruses. In this regard, the search for new antiviral substances continues to be relevant, and the enormous potential of marine resources are a stimulus for the study of marine compounds with antiviral activity in experiments and clinical trials. The highly pathogenic human coronaviruses-severe acute respiratory syndrome-related coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) remain a serious threat to human health. In this review, the authors hope to bring the attention of researchers to the use of biologically active substances of marine origin as potential broad-spectrum antiviral agents targeting common cellular pathways and various stages of the life cycle of different viruses, including coronaviruses. The review has been compiled using references from major databases such as Web of Science, PubMed, Scopus, Elsevier, Springer and Google Scholar (up to June 2020) and keywords such as ‘coronaviruses’, ‘marine organisms’, ‘biologically active substances’, ‘antiviral drugs’, ‘SARS-CoV’, ‘MERS-CoV’, ‘SARS-CoV-2’, ‘3CLpro’, ‘TMPRSS2’, ‘ACE2’. After obtaining all reports from the databases, the papers were carefully analysed in order to find data related to the topic of this review (98 references). Biologically active substances of marine origin, such as flavonoids, phlorotannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, lipids and others substances, can affect coronaviruses at the stages of penetration and entry of the viral particle into the cell, replication of the viral nucleic acid and release of the virion from the cell; they also can act on the host's cellular targets. These natural compounds could be a vital resource in the fight against coronaviruses.
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spelling pubmed-77555862020-12-23 Biologically active compounds from marine organisms in the strategies for combating coronaviruses Zaporozhets, Tatyana S. Besednova, Nataliya N. AIMS Microbiol Review Despite the progress made in immunization and drug development, so far there are no prophylactic vaccines and effective therapies for many viral infections, including infections caused by coronaviruses. In this regard, the search for new antiviral substances continues to be relevant, and the enormous potential of marine resources are a stimulus for the study of marine compounds with antiviral activity in experiments and clinical trials. The highly pathogenic human coronaviruses-severe acute respiratory syndrome-related coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) remain a serious threat to human health. In this review, the authors hope to bring the attention of researchers to the use of biologically active substances of marine origin as potential broad-spectrum antiviral agents targeting common cellular pathways and various stages of the life cycle of different viruses, including coronaviruses. The review has been compiled using references from major databases such as Web of Science, PubMed, Scopus, Elsevier, Springer and Google Scholar (up to June 2020) and keywords such as ‘coronaviruses’, ‘marine organisms’, ‘biologically active substances’, ‘antiviral drugs’, ‘SARS-CoV’, ‘MERS-CoV’, ‘SARS-CoV-2’, ‘3CLpro’, ‘TMPRSS2’, ‘ACE2’. After obtaining all reports from the databases, the papers were carefully analysed in order to find data related to the topic of this review (98 references). Biologically active substances of marine origin, such as flavonoids, phlorotannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, lipids and others substances, can affect coronaviruses at the stages of penetration and entry of the viral particle into the cell, replication of the viral nucleic acid and release of the virion from the cell; they also can act on the host's cellular targets. These natural compounds could be a vital resource in the fight against coronaviruses. AIMS Press 2020-12-07 /pmc/articles/PMC7755586/ /pubmed/33364539 http://dx.doi.org/10.3934/microbiol.2020028 Text en © 2020 the Author(s), licensee AIMS Press This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
spellingShingle Review
Zaporozhets, Tatyana S.
Besednova, Nataliya N.
Biologically active compounds from marine organisms in the strategies for combating coronaviruses
title Biologically active compounds from marine organisms in the strategies for combating coronaviruses
title_full Biologically active compounds from marine organisms in the strategies for combating coronaviruses
title_fullStr Biologically active compounds from marine organisms in the strategies for combating coronaviruses
title_full_unstemmed Biologically active compounds from marine organisms in the strategies for combating coronaviruses
title_short Biologically active compounds from marine organisms in the strategies for combating coronaviruses
title_sort biologically active compounds from marine organisms in the strategies for combating coronaviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755586/
https://www.ncbi.nlm.nih.gov/pubmed/33364539
http://dx.doi.org/10.3934/microbiol.2020028
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