Cargando…
Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female
Aseptic meningitis is most commonly caused by herpes simplex virus (HSV), most often viral subtype 2. While typical meningeal symptoms include headache, photophobia/phonophobia, and nuchal rigidity, these are often much less severe than in bacterial meningitis. Rarely, patients may develop recurrent...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755614/ https://www.ncbi.nlm.nih.gov/pubmed/33376637 http://dx.doi.org/10.7759/cureus.11623 |
_version_ | 1783626385551523840 |
---|---|
author | Kirkland, Zachary Jeffery, Ranese E Conte, Jorge George, Justin Mercado, Roberto |
author_facet | Kirkland, Zachary Jeffery, Ranese E Conte, Jorge George, Justin Mercado, Roberto |
author_sort | Kirkland, Zachary |
collection | PubMed |
description | Aseptic meningitis is most commonly caused by herpes simplex virus (HSV), most often viral subtype 2. While typical meningeal symptoms include headache, photophobia/phonophobia, and nuchal rigidity, these are often much less severe than in bacterial meningitis. Rarely, patients may develop recurrent episodes of aseptic meningitis, sometimes with years between each presentation. A minimum of three episodes with at least one documented viral identification is classified as Mollaret meningitis. First described by Mollaret in 1945, the condition is self-limiting and often requires no intervention or suppressive antivirals. In fact, antiviral therapy may increase frequency of presentation. Our patient presented for her third bout of meningitis, with viral polymerase chain reaction positive for HSV-2 on lumbar puncture. The patient was successfully managed with supportive care without further suppressive antiviral therapy. As the disease is self-limiting, clinician education can mediate patient expectations, reduce unnecessary antiviral usage, and decrease superfluous healthcare resource utilization. |
format | Online Article Text |
id | pubmed-7755614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-77556142020-12-28 Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female Kirkland, Zachary Jeffery, Ranese E Conte, Jorge George, Justin Mercado, Roberto Cureus Internal Medicine Aseptic meningitis is most commonly caused by herpes simplex virus (HSV), most often viral subtype 2. While typical meningeal symptoms include headache, photophobia/phonophobia, and nuchal rigidity, these are often much less severe than in bacterial meningitis. Rarely, patients may develop recurrent episodes of aseptic meningitis, sometimes with years between each presentation. A minimum of three episodes with at least one documented viral identification is classified as Mollaret meningitis. First described by Mollaret in 1945, the condition is self-limiting and often requires no intervention or suppressive antivirals. In fact, antiviral therapy may increase frequency of presentation. Our patient presented for her third bout of meningitis, with viral polymerase chain reaction positive for HSV-2 on lumbar puncture. The patient was successfully managed with supportive care without further suppressive antiviral therapy. As the disease is self-limiting, clinician education can mediate patient expectations, reduce unnecessary antiviral usage, and decrease superfluous healthcare resource utilization. Cureus 2020-11-22 /pmc/articles/PMC7755614/ /pubmed/33376637 http://dx.doi.org/10.7759/cureus.11623 Text en Copyright © 2020, Kirkland et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Kirkland, Zachary Jeffery, Ranese E Conte, Jorge George, Justin Mercado, Roberto Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female |
title | Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female |
title_full | Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female |
title_fullStr | Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female |
title_full_unstemmed | Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female |
title_short | Recurrent Aseptic Meningitis From Herpes Simplex Virus-2: Mollaret's Meningitis in a 30-Year-Old Female |
title_sort | recurrent aseptic meningitis from herpes simplex virus-2: mollaret's meningitis in a 30-year-old female |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755614/ https://www.ncbi.nlm.nih.gov/pubmed/33376637 http://dx.doi.org/10.7759/cureus.11623 |
work_keys_str_mv | AT kirklandzachary recurrentasepticmeningitisfromherpessimplexvirus2mollaretsmeningitisina30yearoldfemale AT jefferyranesee recurrentasepticmeningitisfromherpessimplexvirus2mollaretsmeningitisina30yearoldfemale AT contejorge recurrentasepticmeningitisfromherpessimplexvirus2mollaretsmeningitisina30yearoldfemale AT georgejustin recurrentasepticmeningitisfromherpessimplexvirus2mollaretsmeningitisina30yearoldfemale AT mercadoroberto recurrentasepticmeningitisfromherpessimplexvirus2mollaretsmeningitisina30yearoldfemale |