Cargando…

Therapeutically Administered Ribonucleoside Analogue MK-4482/EIDD-2801 Blocks SARS-CoV-2 Transmission in Ferrets

Detalles Bibliográficos
Autores principales:	Cox, Robert M., Wolf, Josef D., Plemper, Richard K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755744/ https://www.ncbi.nlm.nih.gov/pubmed/33273742 http://dx.doi.org/10.1038/s41564-020-00835-2

Ejemplares similares

Therapeutic MK-4482/EIDD-2801 Blocks SARS-CoV-2 Transmission in Ferrets
por: Cox, Robert M., et al.
Publicado: (2020)

Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine
por: Ahlqvist, Grace P., et al.
Publicado: (2021)

Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2
por: Holman, Wendy, et al.
Publicado: (2021)

A High‐Yielding Synthesis of EIDD‐2801 from Uridine
por: Steiner, Alexander, et al.
Publicado: (2020)

SARS-CoV-2 Infection is Effectively Treated and Prevented by EIDD-2801
por: Wahl, Angela, et al.
Publicado: (2021)

Short Synthesis of Molnupiravir (EIDD-2801) via a Thionated Uridine Intermediate
por: Dey, Raghunath, et al.
Publicado: (2021)

Evaluation of molnupiravir (EIDD-2801) efficacy against SARS-CoV-2 in the rhesus macaque model
por: Johnson, Dylan M., et al.
Publicado: (2023)

Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
por: Ahmed, Ajaz, et al.
Publicado: (2021)

Correction: Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
por: Ahmed, Ajaz, et al.
Publicado: (2022)

Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801
por: Wahl, Angela, et al.
Publicado: (2020)

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning
por: Qin, Zhen, et al.
Publicado: (2021)

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
por: Rosenke, Kyle, et al.
Publicado: (2020)

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
por: Rosenke, Kyle, et al.
Publicado: (2021)

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model
por: Rosenke, Kyle, et al.
Publicado: (2022)

Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
por: Van Rompay, An R, et al.
Publicado: (2003)

Naturally occurring modified ribonucleosides
por: McCown, Phillip J., et al.
Publicado: (2020)

Structural Insights into the Inhibition of Cytosolic 5′-Nucleotidase II (cN-II) by Ribonucleoside 5′-Monophosphate Analogues
por: Gallier, Franck, et al.
Publicado: (2011)

Technical note - elliptic pick up C-2801-50-1
por: Oreberg, P E
Publicado: (1987)

Ribonucleosides for an Artificially Expanded Genetic Information System
por: Kim, Hyo-Joong, et al.
Publicado: (2014)

FERRETS
por: Wolf, Tiffany M.
Publicado: (2009)

Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors
por: Langendries, Lana, et al.
Publicado: (2021)

Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets
por: Nam, Inho, et al.
Publicado: (2018)

Cobalt-assisted route to rare carbocyclic C-ribonucleosides
por: Ojeda-Porras, A. C., et al.
Publicado: (2023)

Ferrets as a model for tuberculosis transmission
por: Gupta, Tuhina, et al.
Publicado: (2022)

Mapping influenza transmission in the ferret model to transmission in humans
por: Buhnerkempe, Michael G, et al.
Publicado: (2015)

Therapeutics in Ferrets
por: Williams, Bruce H.
Publicado: (2000)

miR-4482 and miR-3912 aim for 3ʹUTR of ERG mRNA in prostate cancer
por: Mumtaz, Sidra, et al.
Publicado: (2023)

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
por: Reynard, Olivier, et al.
Publicado: (2015)

Abiotic production of sugar phosphates and uridine ribonucleoside in aqueous microdroplets
por: Nam, Inho, et al.
Publicado: (2017)

Metabolic turnover and dynamics of modified ribonucleosides by (13)C labeling
por: Gameiro, Paulo A., et al.
Publicado: (2021)

Photoactivatable ribonucleosides mark base-specific RNA-binding sites
por: Bae, Jong Woo, et al.
Publicado: (2021)

Ribonucleoside Hydrolases–Structure, Functions, Physiological Role and Practical Uses
por: Shaposhnikov, Leonid A., et al.
Publicado: (2023)

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation
por: Nguyen Van, Tai, et al.
Publicado: (2016)

Modeling Ebola Virus Transmission Using Ferrets
por: de La Vega, Marc-Antoine, et al.
Publicado: (2018)

Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer
por: Yellapu, Nanda Kumar, et al.
Publicado: (2022)

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
por: Cox, Robert M., et al.
Publicado: (2021)

Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors
por: Zhang, Baole, et al.
Publicado: (2020)

Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation
por: You, Changjun, et al.
Publicado: (2017)

Manganese Ions Individually Alter the Reverse Transcription Signature of Modified Ribonucleosides
por: Kristen, Marco, et al.
Publicado: (2020)

A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance
por: Elserafy, Menattallah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tmb7d4ur099njc3l7int829mml