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Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis

MicroRNA (miRNA) has received widespread attention for its role in several key cellular processes such as cell differentiation, cell proliferation, apoptosis, and autoimmune diseases. Although we now have a good understanding of miRNA expression and function, our knowledge regarding the molecular me...

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Detalles Bibliográficos
Autores principales: Liu, Weiwei, Sheng, Li, Nie, Lei, Wen, Xiaoyun, Mo, Xiaodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755821/
https://www.ncbi.nlm.nih.gov/pubmed/33319382
http://dx.doi.org/10.1002/jcla.23489
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author Liu, Weiwei
Sheng, Li
Nie, Lei
Wen, Xiaoyun
Mo, Xiaodan
author_facet Liu, Weiwei
Sheng, Li
Nie, Lei
Wen, Xiaoyun
Mo, Xiaodan
author_sort Liu, Weiwei
collection PubMed
description MicroRNA (miRNA) has received widespread attention for its role in several key cellular processes such as cell differentiation, cell proliferation, apoptosis, and autoimmune diseases. Although we now have a good understanding of miRNA expression and function, our knowledge regarding the molecular mechanism of long non‐coding RNA (lncRNA) is still in its infancy. In this review, we will briefly introduce the definition and function of lncRNA and summarize the interactions between lncRNA and miRNA and their research progress in rheumatoid arthritis (RA). The expression of miR‐16, miR‐146a, miR‐155, and miR‐223 and the interactions between HOTAIR and miR138, ZFAS1 and miR‐27a, and GAPLINC and miR‐575 are representative examples that may augment the understanding of the pathogenesis of RA and help in the development of new biomarkers and target therapies.
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spelling pubmed-77558212020-12-23 Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis Liu, Weiwei Sheng, Li Nie, Lei Wen, Xiaoyun Mo, Xiaodan J Clin Lab Anal Review Article MicroRNA (miRNA) has received widespread attention for its role in several key cellular processes such as cell differentiation, cell proliferation, apoptosis, and autoimmune diseases. Although we now have a good understanding of miRNA expression and function, our knowledge regarding the molecular mechanism of long non‐coding RNA (lncRNA) is still in its infancy. In this review, we will briefly introduce the definition and function of lncRNA and summarize the interactions between lncRNA and miRNA and their research progress in rheumatoid arthritis (RA). The expression of miR‐16, miR‐146a, miR‐155, and miR‐223 and the interactions between HOTAIR and miR138, ZFAS1 and miR‐27a, and GAPLINC and miR‐575 are representative examples that may augment the understanding of the pathogenesis of RA and help in the development of new biomarkers and target therapies. John Wiley and Sons Inc. 2020-12-14 /pmc/articles/PMC7755821/ /pubmed/33319382 http://dx.doi.org/10.1002/jcla.23489 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Article
Liu, Weiwei
Sheng, Li
Nie, Lei
Wen, Xiaoyun
Mo, Xiaodan
Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis
title Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis
title_full Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis
title_fullStr Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis
title_full_unstemmed Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis
title_short Functional interaction between long non‐coding RNA and microRNA in rheumatoid arthritis
title_sort functional interaction between long non‐coding rna and microrna in rheumatoid arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755821/
https://www.ncbi.nlm.nih.gov/pubmed/33319382
http://dx.doi.org/10.1002/jcla.23489
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