Structure of the dopamine D(2) receptor in complex with the antipsychotic drug spiperone

In addition to the serotonin 5-HT(2A) receptor (5-HT(2A)R), the dopamine D(2) receptor (D(2)R) is a key therapeutic target of antipsychotics for the treatment of schizophrenia. The inactive state structures of D(2)R have been described in complex with the inverse agonists risperidone (D(2)R(ris)) an...

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Detalles Bibliográficos
Autores principales: Im, Dohyun, Inoue, Asuka, Fujiwara, Takaaki, Nakane, Takanori, Yamanaka, Yasuaki, Uemura, Tomoko, Mori, Chihiro, Shiimura, Yuki, Kimura, Kanako Terakado, Asada, Hidetsugu, Nomura, Norimichi, Tanaka, Tomoyuki, Yamashita, Ayumi, Nango, Eriko, Tono, Kensuke, Kadji, Francois Marie Ngako, Aoki, Junken, Iwata, So, Shimamura, Tatsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755896/
https://www.ncbi.nlm.nih.gov/pubmed/33353947
http://dx.doi.org/10.1038/s41467-020-20221-0

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