Cargando…

Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2

The ongoing outbreak of COVID-19 has been a serious threat to human health worldwide. The virus SARS-CoV-2 initiates its infection to the human body via the interaction of its spike (S) protein with the human Angiotensin-Converting Enzyme 2 (ACE2) of the host cells. Therefore, understanding the fund...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Yixin, Karki, Chitra B., Du, Dan, Li, Haotian, Wang, Jun, Sobitan, Adebiyi, Teng, Shaolei, Tang, Qiyi, Li, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755986/ https://www.ncbi.nlm.nih.gov/pubmed/33363207 http://dx.doi.org/10.3389/fmolb.2020.591873

Ejemplares similares

Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2
por: Sobitan, Adebiyi, et al.
Publicado: (2021)

Systemic effects of missense mutations on SARS-CoV-2 spike glycoprotein stability and receptor-binding affinity
por: Teng, Shaolei, et al.
Publicado: (2020)

Corrigendum to: Systemic effects of missense mutations on SARS-CoV-2 spike glycoprotein stability and receptor-binding affinity
por: Teng, Shaolei, et al.
Publicado: (2021)

The pH Effects on SARS-CoV and SARS-CoV-2 Spike Proteins in the Process of Binding to hACE2
por: Xie, Yixin, et al.
Publicado: (2021)

The pH Effects on SARS-CoV and SARS-CoV-2 Spike Proteins in the Process of Binding to hACE2
por: Xie, Yixin, et al.
Publicado: (2022)

Biochemical Characterization of SARS-CoV-2 Spike RBD Mutations and Their Impact on ACE2 Receptor Binding
por: Hoter, Abdullah, et al.
Publicado: (2022)

Differences in the organization of interface residues tunes the stability of the SARS-CoV-2 spike-ACE2 complex
por: Miotto, Mattia, et al.
Publicado: (2023)

In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein
por: Rhoades, Raina, et al.
Publicado: (2022)

ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives
por: Saponaro, Federica, et al.
Publicado: (2020)

Identifying Pathways and Networks Associated With the SARS-CoV-2 Cell Receptor ACE2 Based on Gene Expression Profiles in Normal and SARS-CoV-2-Infected Human Tissues
por: Feng, Qiushi, et al.
Publicado: (2020)

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
por: Ahmed, Wesam S., et al.
Publicado: (2022)

Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2
por: Hatmal, Ma’mon M., et al.
Publicado: (2020)

Non-RBM Mutations Impaired SARS-CoV-2 Spike Protein Regulated to the ACE2 Receptor Based on Molecular Dynamic Simulation
por: Du, Yaoqiang, et al.
Publicado: (2021)

Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex
por: Ahmed, Wesam S., et al.
Publicado: (2022)

Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer
por: Yue, Jingwen, et al.
Publicado: (2021)

Cytoplasmic tail determines the membrane trafficking and localization of SARS-CoV-2 spike protein
por: Li, Qinlin, et al.
Publicado: (2022)

SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine Development
por: Malik, Yashpal S., et al.
Publicado: (2021)

Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody Production
por: Zhao, Xiaohui, et al.
Publicado: (2021)

Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms
por: Ali, Amanat, et al.
Publicado: (2020)

Structural dynamic changes in the SARS-CoV and SARS-CoV-2 S spike assemblies upon ACE2 activation
por: Chen, Chengbo, et al.
Publicado: (2022)

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection
por: Shukla, Nidhi, et al.
Publicado: (2021)

Improvement of native structure-based peptides as efficient inhibitors of protein-protein interactions of SARS-CoV-2 spike protein and human ACE2
por: Odolczyk, Norbert, et al.
Publicado: (2022)

The Tissue Distribution of SARS-CoV-2 in Transgenic Mice With Inducible Ubiquitous Expression of hACE2
por: Dolskiy, Alexander A., et al.
Publicado: (2022)

DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2
por: Cleri, Fabrizio, et al.
Publicado: (2021)

The Molecular Basis of the Effect of Temperature on the Structure and Function of SARS-CoV-2 Spike Protein
por: Khan, Faez Iqbal, et al.
Publicado: (2022)

SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host Cells
por: Bharadwaj, Shiv, et al.
Publicado: (2021)

Mechanistic Origin of Different Binding Affinities of SARS-CoV and SARS-CoV-2 Spike RBDs to Human ACE2
por: Zhang, Zhi-Bi, et al.
Publicado: (2022)

SARS-CoV-2 spike and ACE2 entanglement-like binding
por: Pregnolato, Massimo, et al.
Publicado: (2023)

Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2
por: Ge, Shuai, et al.
Publicado: (2021)

Investigation of the Effect of Temperature on the Structure of SARS-CoV-2 Spike Protein by Molecular Dynamics Simulations
por: Rath, Soumya Lipsa, et al.
Publicado: (2020)

Shape Complementarity Optimization of Antibody–Antigen Interfaces: The Application to SARS-CoV-2 Spike Protein
por: De Lauro, Alfredo, et al.
Publicado: (2022)

Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS‐CoV‐1 and SARS‐CoV‐2)
por: Rombel‐Bryzek, Agnieszka, et al.
Publicado: (2022)

Revealing the Mechanism of SARS-CoV-2 Spike Protein Binding With ACE2
Publicado: (2020)

SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex
por: Vásquez, Viviana, et al.
Publicado: (2022)

Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike
por: Wrobel, Antoni G.
Publicado: (2023)

Design and Identification of Inhibitors for the Spike-ACE2 Target of SARS-CoV-2
por: Bastos, Ruan S., et al.
Publicado: (2023)

SARS-CoV-2 Virion Stabilization by Zn Binding
por: Morante, Silvia, et al.
Publicado: (2020)

Drug Weaponry to Fight Against SARS-CoV-2
por: Cabezón, Elena, et al.
Publicado: (2020)

Antibodies and Vaccines Target RBD of SARS-CoV-2
por: Min, Long, et al.
Publicado: (2021)

Modeling of the thermal properties of SARS-CoV-2 S-protein
por: Niu, Ziyuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6aevfls9rdjq0gd4krrujhbkqc