Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer

Virus positive Merkel cell carcinoma (VP-MCC) is an aggressive but immunogenic skin malignancy driven by Merkel cell polyomavirus (MCPyV) T antigen (TAg). Since adoptive T cell transfer (ACT) can be effective against virus-driven malignancies, we set out to develop a methodology for generating MCPyV...

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Detalles Bibliográficos
Autores principales: Davies, Sarah I., Barrett, John, Wong, Susan, Chang, Mark Jesse, Muranski, Pawel J., Brownell, Isaac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756016/
https://www.ncbi.nlm.nih.gov/pubmed/33362774
http://dx.doi.org/10.3389/fimmu.2020.592721

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