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Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder mediated by NMDAR antibodies, typically manifesting as behavioral complaints, psychosis, seizures, movement disorders, hypoventilation, and autonomic dysfunction. In recent years, the predisposing factors and pathophys...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756053/ https://www.ncbi.nlm.nih.gov/pubmed/33362777 http://dx.doi.org/10.3389/fimmu.2020.595417 |
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author | Huang, Ying Wang, Qian Zeng, Silin Zhang, Yaqing Zou, Liangyu Fu, Xuejun Xu, Qianhui |
author_facet | Huang, Ying Wang, Qian Zeng, Silin Zhang, Yaqing Zou, Liangyu Fu, Xuejun Xu, Qianhui |
author_sort | Huang, Ying |
collection | PubMed |
description | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder mediated by NMDAR antibodies, typically manifesting as behavioral complaints, psychosis, seizures, movement disorders, hypoventilation, and autonomic dysfunction. In recent years, the predisposing factors and pathophysiological mechanisms of anti-NMDAR encephalitis have been tried to be clarified. It has been recognized that an overlap may be observed between anti-NMDAR encephalitis and inflammatory demyelinating disease. However, anti-NMDAR encephalitis is rarely associated with multiple sclerosis. Here, we describe a Chinese female patient diagnosed with relapsing remitting multiple sclerosis who developed anti-NMDAR encephalitis. Further, we discuss the previously reported literature. |
format | Online Article Text |
id | pubmed-7756053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77560532020-12-24 Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature Huang, Ying Wang, Qian Zeng, Silin Zhang, Yaqing Zou, Liangyu Fu, Xuejun Xu, Qianhui Front Immunol Immunology Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder mediated by NMDAR antibodies, typically manifesting as behavioral complaints, psychosis, seizures, movement disorders, hypoventilation, and autonomic dysfunction. In recent years, the predisposing factors and pathophysiological mechanisms of anti-NMDAR encephalitis have been tried to be clarified. It has been recognized that an overlap may be observed between anti-NMDAR encephalitis and inflammatory demyelinating disease. However, anti-NMDAR encephalitis is rarely associated with multiple sclerosis. Here, we describe a Chinese female patient diagnosed with relapsing remitting multiple sclerosis who developed anti-NMDAR encephalitis. Further, we discuss the previously reported literature. Frontiers Media S.A. 2020-12-09 /pmc/articles/PMC7756053/ /pubmed/33362777 http://dx.doi.org/10.3389/fimmu.2020.595417 Text en Copyright © 2020 Huang, Wang, Zeng, Zhang, Zou, Fu and Xu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Huang, Ying Wang, Qian Zeng, Silin Zhang, Yaqing Zou, Liangyu Fu, Xuejun Xu, Qianhui Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature |
title | Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature |
title_full | Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature |
title_fullStr | Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature |
title_full_unstemmed | Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature |
title_short | Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature |
title_sort | case report: overlapping multiple sclerosis with anti-n-methyl-d-aspartate receptor encephalitis: a case report and review of literature |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756053/ https://www.ncbi.nlm.nih.gov/pubmed/33362777 http://dx.doi.org/10.3389/fimmu.2020.595417 |
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