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Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder mediated by NMDAR antibodies, typically manifesting as behavioral complaints, psychosis, seizures, movement disorders, hypoventilation, and autonomic dysfunction. In recent years, the predisposing factors and pathophys...

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Autores principales: Huang, Ying, Wang, Qian, Zeng, Silin, Zhang, Yaqing, Zou, Liangyu, Fu, Xuejun, Xu, Qianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756053/
https://www.ncbi.nlm.nih.gov/pubmed/33362777
http://dx.doi.org/10.3389/fimmu.2020.595417
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author Huang, Ying
Wang, Qian
Zeng, Silin
Zhang, Yaqing
Zou, Liangyu
Fu, Xuejun
Xu, Qianhui
author_facet Huang, Ying
Wang, Qian
Zeng, Silin
Zhang, Yaqing
Zou, Liangyu
Fu, Xuejun
Xu, Qianhui
author_sort Huang, Ying
collection PubMed
description Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder mediated by NMDAR antibodies, typically manifesting as behavioral complaints, psychosis, seizures, movement disorders, hypoventilation, and autonomic dysfunction. In recent years, the predisposing factors and pathophysiological mechanisms of anti-NMDAR encephalitis have been tried to be clarified. It has been recognized that an overlap may be observed between anti-NMDAR encephalitis and inflammatory demyelinating disease. However, anti-NMDAR encephalitis is rarely associated with multiple sclerosis. Here, we describe a Chinese female patient diagnosed with relapsing remitting multiple sclerosis who developed anti-NMDAR encephalitis. Further, we discuss the previously reported literature.
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spelling pubmed-77560532020-12-24 Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature Huang, Ying Wang, Qian Zeng, Silin Zhang, Yaqing Zou, Liangyu Fu, Xuejun Xu, Qianhui Front Immunol Immunology Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder mediated by NMDAR antibodies, typically manifesting as behavioral complaints, psychosis, seizures, movement disorders, hypoventilation, and autonomic dysfunction. In recent years, the predisposing factors and pathophysiological mechanisms of anti-NMDAR encephalitis have been tried to be clarified. It has been recognized that an overlap may be observed between anti-NMDAR encephalitis and inflammatory demyelinating disease. However, anti-NMDAR encephalitis is rarely associated with multiple sclerosis. Here, we describe a Chinese female patient diagnosed with relapsing remitting multiple sclerosis who developed anti-NMDAR encephalitis. Further, we discuss the previously reported literature. Frontiers Media S.A. 2020-12-09 /pmc/articles/PMC7756053/ /pubmed/33362777 http://dx.doi.org/10.3389/fimmu.2020.595417 Text en Copyright © 2020 Huang, Wang, Zeng, Zhang, Zou, Fu and Xu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Ying
Wang, Qian
Zeng, Silin
Zhang, Yaqing
Zou, Liangyu
Fu, Xuejun
Xu, Qianhui
Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature
title Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature
title_full Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature
title_fullStr Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature
title_full_unstemmed Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature
title_short Case Report: Overlapping Multiple Sclerosis With Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature
title_sort case report: overlapping multiple sclerosis with anti-n-methyl-d-aspartate receptor encephalitis: a case report and review of literature
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756053/
https://www.ncbi.nlm.nih.gov/pubmed/33362777
http://dx.doi.org/10.3389/fimmu.2020.595417
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