Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers

Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach to monitor human health and disease but have not been utilized for astronauts. Here, we profile cfDNA characteristics, including fragment size, cellular deconvolution, and nucleosome positioning, in an astronau...

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Detalles Bibliográficos
Autores principales: Bezdan, Daniela, Grigorev, Kirill, Meydan, Cem, Pelissier Vatter, Fanny A., Cioffi, Michele, Rao, Varsha, MacKay, Matthew, Nakahira, Kiichi, Burnham, Philip, Afshinnekoo, Ebrahim, Westover, Craig, Butler, Daniel, Mozsary, Chris, Donahoe, Timothy, Foox, Jonathan, Mishra, Tejaswini, Lucotti, Serena, Rana, Brinda K., Melnick, Ari M., Zhang, Haiying, Matei, Irina, Kelsen, David, Yu, Kenneth, Lyden, David C., Taylor, Lynn, Bailey, Susan M., Snyder, Michael P., Garrett-Bakelman, Francine E., Ossowski, Stephan, De Vlaminck, Iwijn, Mason, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756145/
https://www.ncbi.nlm.nih.gov/pubmed/33376973
http://dx.doi.org/10.1016/j.isci.2020.101844

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