Identification and characterization of functional long noncoding RNAs in cancer

Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. However, whether lncRNA alterations are passengers acquired during cancer progression or...

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Detalles Bibliográficos
Autores principales: Olivero, Christiane E., Dimitrova, Nadya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Invited Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756267/
https://www.ncbi.nlm.nih.gov/pubmed/33058262
http://dx.doi.org/10.1096/fj.202001951R
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author Olivero, Christiane E.
Dimitrova, Nadya
author_facet Olivero, Christiane E.
Dimitrova, Nadya
author_sort Olivero, Christiane E.
collection PubMed
description Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. However, whether lncRNA alterations are passengers acquired during cancer progression or can act as tumorigenic drivers is a topic of ongoing investigation. In this review, we examine the current methodologies underlying the identification of cancer‐associated lncRNAs and highlight important considerations for evaluating their biological significance as cancer drivers.
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spelling pubmed-77562672020-12-28 Identification and characterization of functional long noncoding RNAs in cancer Olivero, Christiane E. Dimitrova, Nadya FASEB J Invited Article Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. However, whether lncRNA alterations are passengers acquired during cancer progression or can act as tumorigenic drivers is a topic of ongoing investigation. In this review, we examine the current methodologies underlying the identification of cancer‐associated lncRNAs and highlight important considerations for evaluating their biological significance as cancer drivers. John Wiley and Sons Inc. 2020-10-15 2020-12 /pmc/articles/PMC7756267/ /pubmed/33058262 http://dx.doi.org/10.1096/fj.202001951R Text en © 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Invited Article
Olivero, Christiane E.
Dimitrova, Nadya
Identification and characterization of functional long noncoding RNAs in cancer
title Identification and characterization of functional long noncoding RNAs in cancer
title_full Identification and characterization of functional long noncoding RNAs in cancer
title_fullStr Identification and characterization of functional long noncoding RNAs in cancer
title_full_unstemmed Identification and characterization of functional long noncoding RNAs in cancer
title_short Identification and characterization of functional long noncoding RNAs in cancer
title_sort identification and characterization of functional long noncoding rnas in cancer
topic Invited Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756267/
https://www.ncbi.nlm.nih.gov/pubmed/33058262
http://dx.doi.org/10.1096/fj.202001951R
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AT dimitrovanadya identificationandcharacterizationoffunctionallongnoncodingrnasincancer

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