Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction

A constant current protocol, employing undivided cells, a remarkably low supporting electrolyte concentration, inexpensive electrode materials, and a straightforward precursor synthesis enabling a novel access to N‐protected carbazoles by anodic N,C bond formation using directly generated amidyl rad...

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Detalles Bibliográficos
Autores principales: Kehl, Anton, Schupp, Niclas, Breising, Valentina M., Schollmeyer, Dieter, Waldvogel, Siegfried R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756279/
https://www.ncbi.nlm.nih.gov/pubmed/32737905
http://dx.doi.org/10.1002/chem.202003430
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author Kehl, Anton
Schupp, Niclas
Breising, Valentina M.
Schollmeyer, Dieter
Waldvogel, Siegfried R.
author_facet Kehl, Anton
Schupp, Niclas
Breising, Valentina M.
Schollmeyer, Dieter
Waldvogel, Siegfried R.
author_sort Kehl, Anton
collection PubMed
description A constant current protocol, employing undivided cells, a remarkably low supporting electrolyte concentration, inexpensive electrode materials, and a straightforward precursor synthesis enabling a novel access to N‐protected carbazoles by anodic N,C bond formation using directly generated amidyl radicals is reported. Scalability of the reaction is demonstrated and an easy deblocking of the benzoyl protecting group is presented.
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spelling pubmed-77562792020-12-28 Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction Kehl, Anton Schupp, Niclas Breising, Valentina M. Schollmeyer, Dieter Waldvogel, Siegfried R. Chemistry Communications A constant current protocol, employing undivided cells, a remarkably low supporting electrolyte concentration, inexpensive electrode materials, and a straightforward precursor synthesis enabling a novel access to N‐protected carbazoles by anodic N,C bond formation using directly generated amidyl radicals is reported. Scalability of the reaction is demonstrated and an easy deblocking of the benzoyl protecting group is presented. John Wiley and Sons Inc. 2020-10-29 2020-12-04 /pmc/articles/PMC7756279/ /pubmed/32737905 http://dx.doi.org/10.1002/chem.202003430 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Kehl, Anton
Schupp, Niclas
Breising, Valentina M.
Schollmeyer, Dieter
Waldvogel, Siegfried R.
Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction
title Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction
title_full Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction
title_fullStr Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction
title_full_unstemmed Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction
title_short Electrochemical Synthesis of Carbazoles by Dehydrogenative Coupling Reaction
title_sort electrochemical synthesis of carbazoles by dehydrogenative coupling reaction
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756279/
https://www.ncbi.nlm.nih.gov/pubmed/32737905
http://dx.doi.org/10.1002/chem.202003430
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