Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy

This article describes a case of metastatic, bulky, high‐grade, rapidly progressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion originating from the left kidney that demonstrated a dramatic, deep response within 2 cycles of treatment with a regimen used for patients with Ewing sarcoma and an on...

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Autor principal: Shenoy, Niraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cancer Case Conundrums
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756288/
https://www.ncbi.nlm.nih.gov/pubmed/33048366
http://dx.doi.org/10.1002/cncr.33220
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author Shenoy, Niraj
author_facet Shenoy, Niraj
author_sort Shenoy, Niraj
collection PubMed
description This article describes a case of metastatic, bulky, high‐grade, rapidly progressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion originating from the left kidney that demonstrated a dramatic, deep response within 2 cycles of treatment with a regimen used for patients with Ewing sarcoma and an ongoing sustained response of >10 months. To the author's knowledge, this is the first report of a rapid and deep response using a systemic therapy regimen in a patient with myoepithelial carcinoma with EWSR1‐POU5F1 fusion.
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spelling pubmed-77562882020-12-28 Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy Shenoy, Niraj Cancer Cancer Case Conundrums This article describes a case of metastatic, bulky, high‐grade, rapidly progressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion originating from the left kidney that demonstrated a dramatic, deep response within 2 cycles of treatment with a regimen used for patients with Ewing sarcoma and an ongoing sustained response of >10 months. To the author's knowledge, this is the first report of a rapid and deep response using a systemic therapy regimen in a patient with myoepithelial carcinoma with EWSR1‐POU5F1 fusion. John Wiley and Sons Inc. 2020-10-13 2020-12-15 /pmc/articles/PMC7756288/ /pubmed/33048366 http://dx.doi.org/10.1002/cncr.33220 Text en © 2020 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Cancer Case Conundrums
Shenoy, Niraj
Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy
title Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy
title_full Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy
title_fullStr Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy
title_full_unstemmed Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy
title_short Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy
title_sort aggressive myoepithelial carcinoma with ewsr1‐pou5f1 fusion highly responsive to ewing sarcoma combination chemotherapy
topic Cancer Case Conundrums
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756288/
https://www.ncbi.nlm.nih.gov/pubmed/33048366
http://dx.doi.org/10.1002/cncr.33220
work_keys_str_mv AT shenoyniraj aggressivemyoepithelialcarcinomawithewsr1pou5f1fusionhighlyresponsivetoewingsarcomacombinationchemotherapy

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