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Status and outlook for acaricide and insecticide discovery

To guarantee sustainability and progress, the agrochemical industry is faced with several major challenges. Currently, loss of active ingredients due to consumer perception, changing grower needs and ever‐changing regulatory requirements is far higher than the number being introduced into the market...

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Autor principal: Jeschke, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JohncWiley & Sons, Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756306/
https://www.ncbi.nlm.nih.gov/pubmed/32926594
http://dx.doi.org/10.1002/ps.6084
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author Jeschke, Peter
author_facet Jeschke, Peter
author_sort Jeschke, Peter
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description To guarantee sustainability and progress, the agrochemical industry is faced with several major challenges. Currently, loss of active ingredients due to consumer perception, changing grower needs and ever‐changing regulatory requirements is far higher than the number being introduced into the market. Therefore, there is a need to develop new products that can provide improved efficacy, selectivity and favorable environmental profiles. Strategies to achieve these goals are the search for acaricides and insecticides with new modes of action, or the discovery of novel molecules with activity on the most attractive target sites having resistance breaking properties against pest species. In this context, the introduction of halogen atoms or asymmetric centers into an active ingredient remains an important tool to modulate their properties, but so too is the pro‐pesticide concept. This review gives an overview of agrochemicals launched over the past 8 years, reflects new insights into known mechanisms of action, and describes the status and outlook for acaricide and insecticide discovery.
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spelling pubmed-77563062020-12-28 Status and outlook for acaricide and insecticide discovery Jeschke, Peter Pest Manag Sci Reviews To guarantee sustainability and progress, the agrochemical industry is faced with several major challenges. Currently, loss of active ingredients due to consumer perception, changing grower needs and ever‐changing regulatory requirements is far higher than the number being introduced into the market. Therefore, there is a need to develop new products that can provide improved efficacy, selectivity and favorable environmental profiles. Strategies to achieve these goals are the search for acaricides and insecticides with new modes of action, or the discovery of novel molecules with activity on the most attractive target sites having resistance breaking properties against pest species. In this context, the introduction of halogen atoms or asymmetric centers into an active ingredient remains an important tool to modulate their properties, but so too is the pro‐pesticide concept. This review gives an overview of agrochemicals launched over the past 8 years, reflects new insights into known mechanisms of action, and describes the status and outlook for acaricide and insecticide discovery. JohncWiley & Sons, Ltd. 2020-09-28 2021-01 /pmc/articles/PMC7756306/ /pubmed/32926594 http://dx.doi.org/10.1002/ps.6084 Text en © 2020 The Author. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Jeschke, Peter
Status and outlook for acaricide and insecticide discovery
title Status and outlook for acaricide and insecticide discovery
title_full Status and outlook for acaricide and insecticide discovery
title_fullStr Status and outlook for acaricide and insecticide discovery
title_full_unstemmed Status and outlook for acaricide and insecticide discovery
title_short Status and outlook for acaricide and insecticide discovery
title_sort status and outlook for acaricide and insecticide discovery
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756306/
https://www.ncbi.nlm.nih.gov/pubmed/32926594
http://dx.doi.org/10.1002/ps.6084
work_keys_str_mv AT jeschkepeter statusandoutlookforacaricideandinsecticidediscovery