Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation

The Pd‐catalyzed directed thiocyanation reaction of arenes and heteroarenes by C−H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yie...

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Autores principales: Gao, Mélissa, Chen, Mu‐Yi, Pannecoucke, Xavier, Jubault, Philippe, Besset, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756308/
https://www.ncbi.nlm.nih.gov/pubmed/32833317
http://dx.doi.org/10.1002/chem.202003521
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author Gao, Mélissa
Chen, Mu‐Yi
Pannecoucke, Xavier
Jubault, Philippe
Besset, Tatiana
author_facet Gao, Mélissa
Chen, Mu‐Yi
Pannecoucke, Xavier
Jubault, Philippe
Besset, Tatiana
author_sort Gao, Mélissa
collection PubMed
description The Pd‐catalyzed directed thiocyanation reaction of arenes and heteroarenes by C−H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yield). Post‐functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN‐containing molecules into value‐added scaffolds.
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spelling pubmed-77563082020-12-28 Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation Gao, Mélissa Chen, Mu‐Yi Pannecoucke, Xavier Jubault, Philippe Besset, Tatiana Chemistry Communications The Pd‐catalyzed directed thiocyanation reaction of arenes and heteroarenes by C−H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yield). Post‐functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN‐containing molecules into value‐added scaffolds. John Wiley and Sons Inc. 2020-11-03 2020-12-01 /pmc/articles/PMC7756308/ /pubmed/32833317 http://dx.doi.org/10.1002/chem.202003521 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Gao, Mélissa
Chen, Mu‐Yi
Pannecoucke, Xavier
Jubault, Philippe
Besset, Tatiana
Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation
title Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation
title_full Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation
title_fullStr Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation
title_full_unstemmed Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation
title_short Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation
title_sort pd‐catalyzed directed thiocyanation reaction by c−h bond activation
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756308/
https://www.ncbi.nlm.nih.gov/pubmed/32833317
http://dx.doi.org/10.1002/chem.202003521
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AT jubaultphilippe pdcatalyzeddirectedthiocyanationreactionbychbondactivation
AT bessettatiana pdcatalyzeddirectedthiocyanationreactionbychbondactivation

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