Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)

Ceramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step of sphingomyelin biosynthesis. Usually, CERT ligands are evaluated in tedious binding assays or non‐homogenous transfer assays using ra...

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Detalles Bibliográficos
Autores principales: Samaha, Doaa, Hamdo, Housam H., Cong, Xiaojing, Schumacher, Fabian, Banhart, Sebastian, Aglar, Öznur, Möller, Heiko M., Heuer, Dagmar, Kleuser, Burkhard, Saied, Essa M., Arenz, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756341/
https://www.ncbi.nlm.nih.gov/pubmed/33047409
http://dx.doi.org/10.1002/chem.202003283

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