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Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents
Tuberculosis is one of the leading cause of death in the world, mainly due to the increasing number of multidrug‐resistant TB (MDR‐TB) and extensively drug‐resistant TB (XDR‐TB) strains. Factors such as the HIV pandemic contribute further. Also, the ineffectiveness of the chemotherapy in current use...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756396/ https://www.ncbi.nlm.nih.gov/pubmed/32844566 http://dx.doi.org/10.1002/cmdc.202000580 |
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author | Bvumbi, Mpelegeng Victoria |
author_facet | Bvumbi, Mpelegeng Victoria |
author_sort | Bvumbi, Mpelegeng Victoria |
collection | PubMed |
description | Tuberculosis is one of the leading cause of death in the world, mainly due to the increasing number of multidrug‐resistant TB (MDR‐TB) and extensively drug‐resistant TB (XDR‐TB) strains. Factors such as the HIV pandemic contribute further. Also, the ineffectiveness of the chemotherapy in current use increases the mortality rate. Therefore, new and repurposed antituberculosis drugs are urgently needed for the treatment of MDR‐TB, and riminophenazines are among those drugs that are being reinvestigated for their potential in the treatment of TB. This review delivers a brief historical account of riminophenazines, their general synthesis, mechanisms of action, and their physicochemical properties. The discussion is limited to those studies that investigated the activity of these compounds as antituberculosis agents. Given their unique properties, this review will be of great significance in giving direction towards the design and development of new riminophenazine analogues. |
format | Online Article Text |
id | pubmed-7756396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77563962020-12-28 Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents Bvumbi, Mpelegeng Victoria ChemMedChem Minireviews Tuberculosis is one of the leading cause of death in the world, mainly due to the increasing number of multidrug‐resistant TB (MDR‐TB) and extensively drug‐resistant TB (XDR‐TB) strains. Factors such as the HIV pandemic contribute further. Also, the ineffectiveness of the chemotherapy in current use increases the mortality rate. Therefore, new and repurposed antituberculosis drugs are urgently needed for the treatment of MDR‐TB, and riminophenazines are among those drugs that are being reinvestigated for their potential in the treatment of TB. This review delivers a brief historical account of riminophenazines, their general synthesis, mechanisms of action, and their physicochemical properties. The discussion is limited to those studies that investigated the activity of these compounds as antituberculosis agents. Given their unique properties, this review will be of great significance in giving direction towards the design and development of new riminophenazine analogues. John Wiley and Sons Inc. 2020-10-15 2020-12-03 /pmc/articles/PMC7756396/ /pubmed/32844566 http://dx.doi.org/10.1002/cmdc.202000580 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireviews Bvumbi, Mpelegeng Victoria Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents |
title | Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents |
title_full | Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents |
title_fullStr | Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents |
title_full_unstemmed | Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents |
title_short | Activity of Riminophenazines against Mycobacterium tuberculosis: A Review of Studies that Might be Contenders for Use as Antituberculosis Agents |
title_sort | activity of riminophenazines against mycobacterium tuberculosis: a review of studies that might be contenders for use as antituberculosis agents |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756396/ https://www.ncbi.nlm.nih.gov/pubmed/32844566 http://dx.doi.org/10.1002/cmdc.202000580 |
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