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Suppression of Formylation Provides an Alternative Approach to Vacant Codon Creation in Bacterial In Vitro Translation

Genetic code reprogramming is a powerful approach to controlled protein modification. A remaining challenge, however, is the generation of vacant codons. We targeted the initiation machinery of E. coli, showing that restriction of the formyl donor or inhibition of the formyl transferase during in vi...

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Detalles Bibliográficos
Autores principales: Liu, Minglong, Thijssen, Vito, Jongkees, Seino A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756408/
https://www.ncbi.nlm.nih.gov/pubmed/32840944
http://dx.doi.org/10.1002/anie.202003779