Recyclable Ruthenium Catalyst for Distal meta‐C−H Activation

We disclose the unprecedented hybrid‐ruthenium catalysis for distal meta‐C−H activation. The hybrid‐ruthenium catalyst was recyclable, as was proven by various heterogeneity tests, and fully characterized with various microscopic and spectroscopic techniques, highlighting the physical and chemical stability. Thereby, the hybrid‐ruthenium catalysis proved broadly applicable for meta‐C−H alkylations of among others purine‐based nucleosides and natural product conjugates. Additionally, its versatility was further reflected by meta‐C−H activations through visible‐light irradiation, as well as para‐selective C−H activations.