Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas

Cystic fibrosis transmembrane conductance regulator (CFTR) is an unusual ABC transporter. It acts as an anion‐selective channel that drives osmotic fluid transport across many epithelia. In the gut, CFTR is crucial for maintaining fluid and acid‐base homeostasis, and its activity is tightly controll...

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Detalles Bibliográficos
Autores principales: de Jonge, Hugo R., Ardelean, Maria C., Bijvelds, Marcel J. C., Vergani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756540/
https://www.ncbi.nlm.nih.gov/pubmed/33113586
http://dx.doi.org/10.1002/1873-3468.13971

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