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Structures of ABC transporters: handle with care

In the past two decades, the ATP‐binding cassette (ABC) transporters' field has undergone a structural revolution. The importance of structural biology to the development of the field of ABC transporters cannot be overstated, as the ensemble of structures not only revealed the architecture of A...

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Detalles Bibliográficos
Autores principales: Lewinson, Oded, Orelle, Cédric, Seeger, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756565/
https://www.ncbi.nlm.nih.gov/pubmed/33098660
http://dx.doi.org/10.1002/1873-3468.13966
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author Lewinson, Oded
Orelle, Cédric
Seeger, Markus A.
author_facet Lewinson, Oded
Orelle, Cédric
Seeger, Markus A.
author_sort Lewinson, Oded
collection PubMed
description In the past two decades, the ATP‐binding cassette (ABC) transporters' field has undergone a structural revolution. The importance of structural biology to the development of the field of ABC transporters cannot be overstated, as the ensemble of structures not only revealed the architecture of ABC transporters but also shaped our mechanistic view of these remarkable molecular machines. Nevertheless, we advocate that the mechanistic interpretation of the structures is not trivial and should be carried out with prudence. Herein, we bring several examples of structures of ABC transporters that merit re‐interpretation via careful comparison to experimental data. We propose that it is of the upmost importance to place new structures within the context of the available experimental data.
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spelling pubmed-77565652020-12-28 Structures of ABC transporters: handle with care Lewinson, Oded Orelle, Cédric Seeger, Markus A. FEBS Lett Perspectives In the past two decades, the ATP‐binding cassette (ABC) transporters' field has undergone a structural revolution. The importance of structural biology to the development of the field of ABC transporters cannot be overstated, as the ensemble of structures not only revealed the architecture of ABC transporters but also shaped our mechanistic view of these remarkable molecular machines. Nevertheless, we advocate that the mechanistic interpretation of the structures is not trivial and should be carried out with prudence. Herein, we bring several examples of structures of ABC transporters that merit re‐interpretation via careful comparison to experimental data. We propose that it is of the upmost importance to place new structures within the context of the available experimental data. John Wiley and Sons Inc. 2020-11-21 2020-12 /pmc/articles/PMC7756565/ /pubmed/33098660 http://dx.doi.org/10.1002/1873-3468.13966 Text en © 2020 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspectives
Lewinson, Oded
Orelle, Cédric
Seeger, Markus A.
Structures of ABC transporters: handle with care
title Structures of ABC transporters: handle with care
title_full Structures of ABC transporters: handle with care
title_fullStr Structures of ABC transporters: handle with care
title_full_unstemmed Structures of ABC transporters: handle with care
title_short Structures of ABC transporters: handle with care
title_sort structures of abc transporters: handle with care
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756565/
https://www.ncbi.nlm.nih.gov/pubmed/33098660
http://dx.doi.org/10.1002/1873-3468.13966
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