Cargando…

Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans

NEW FINDINGS: What is the central question of this study? In male lowlanders, does hypoxia modulate thermoregulatory effector responses during repeated whole‐body cold stress encountered in a single day? What is the main finding and its importance? A ∼10 h sustained exposure to hypoxia appears to me...

Descripción completa

Detalles Bibliográficos
Autores principales: Keramidas, Michail E., Kölegård, Roger, Eiken, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756580/
https://www.ncbi.nlm.nih.gov/pubmed/33140429
http://dx.doi.org/10.1113/EP089070
_version_ 1783626574178811904
author Keramidas, Michail E.
Kölegård, Roger
Eiken, Ola
author_facet Keramidas, Michail E.
Kölegård, Roger
Eiken, Ola
author_sort Keramidas, Michail E.
collection PubMed
description NEW FINDINGS: What is the central question of this study? In male lowlanders, does hypoxia modulate thermoregulatory effector responses during repeated whole‐body cold stress encountered in a single day? What is the main finding and its importance? A ∼10 h sustained exposure to hypoxia appears to mediate a gradual upregulation of endogenous heat production, preventing the progressive hypothermic response prompted by serial cold stimuli. Also, hypoxia progressively degrades mood, and compounds the perceived thermal discomfort, and sensations of fatigue and coldness. ABSTRACT: We examined whether hypoxia would modulate thermoeffector responses during repeated cold stress encountered in a single day. Eleven men completed two ∼10 h sessions, while breathing, in normobaria, either normoxia or hypoxia ([Formula: see text]: 12 kPa). During each session, subjects underwent sequentially three 120 min immersions to the chest in 20°C water (CWI), interspersed by 120 min rewarming. In normoxia, the final drop in rectal temperature (T (rec)) was greater in the third (∼1.2°C) than in the first and second (∼0.9°C) CWIs (P < 0.05). The first hypoxic CWI augmented the T (rec) fall (∼1.2°C; P = 0.002), but the drop in T (rec) did not vary between the three hypoxic CWIs (P = 0.99). In normoxia, the metabolic heat production ([Formula: see text]) was greater during the first half of the third CWI than during the corresponding part of the first CWI (P = 0.02); yet the difference was blunted during the second half of the CWIs (P = 0.89). In hypoxia, by contrast, the increase in [Formula: see text] was augmented by ∼25% throughout the third CWI (P < 0.01). Regardless of the breathing condition, the cold‐induced elevation in mean arterial pressure was blunted in the second and third CWI (P < 0.05). Hypoxia aggravated the sensation of coldness (P = 0.05) and thermal discomfort (P = 0.04) during the second half of the third CWI. The present findings therefore demonstrate that prolonged hypoxia mediates, in a gradual manner, metabolic and thermoperceptual sensitization to repeated cold stress.
format Online
Article
Text
id pubmed-7756580
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-77565802020-12-28 Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans Keramidas, Michail E. Kölegård, Roger Eiken, Ola Exp Physiol Research Papers NEW FINDINGS: What is the central question of this study? In male lowlanders, does hypoxia modulate thermoregulatory effector responses during repeated whole‐body cold stress encountered in a single day? What is the main finding and its importance? A ∼10 h sustained exposure to hypoxia appears to mediate a gradual upregulation of endogenous heat production, preventing the progressive hypothermic response prompted by serial cold stimuli. Also, hypoxia progressively degrades mood, and compounds the perceived thermal discomfort, and sensations of fatigue and coldness. ABSTRACT: We examined whether hypoxia would modulate thermoeffector responses during repeated cold stress encountered in a single day. Eleven men completed two ∼10 h sessions, while breathing, in normobaria, either normoxia or hypoxia ([Formula: see text]: 12 kPa). During each session, subjects underwent sequentially three 120 min immersions to the chest in 20°C water (CWI), interspersed by 120 min rewarming. In normoxia, the final drop in rectal temperature (T (rec)) was greater in the third (∼1.2°C) than in the first and second (∼0.9°C) CWIs (P < 0.05). The first hypoxic CWI augmented the T (rec) fall (∼1.2°C; P = 0.002), but the drop in T (rec) did not vary between the three hypoxic CWIs (P = 0.99). In normoxia, the metabolic heat production ([Formula: see text]) was greater during the first half of the third CWI than during the corresponding part of the first CWI (P = 0.02); yet the difference was blunted during the second half of the CWIs (P = 0.89). In hypoxia, by contrast, the increase in [Formula: see text] was augmented by ∼25% throughout the third CWI (P < 0.01). Regardless of the breathing condition, the cold‐induced elevation in mean arterial pressure was blunted in the second and third CWI (P < 0.05). Hypoxia aggravated the sensation of coldness (P = 0.05) and thermal discomfort (P = 0.04) during the second half of the third CWI. The present findings therefore demonstrate that prolonged hypoxia mediates, in a gradual manner, metabolic and thermoperceptual sensitization to repeated cold stress. John Wiley and Sons Inc. 2020-11-16 2020-12-01 /pmc/articles/PMC7756580/ /pubmed/33140429 http://dx.doi.org/10.1113/EP089070 Text en © 2020 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Papers
Keramidas, Michail E.
Kölegård, Roger
Eiken, Ola
Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans
title Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans
title_full Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans
title_fullStr Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans
title_full_unstemmed Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans
title_short Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans
title_sort hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole‐body cold stress in humans
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756580/
https://www.ncbi.nlm.nih.gov/pubmed/33140429
http://dx.doi.org/10.1113/EP089070
work_keys_str_mv AT keramidasmichaile hypoxiagraduallyaugmentsmetabolicandthermoperceptualresponsivenesstorepeatedwholebodycoldstressinhumans
AT kolegardroger hypoxiagraduallyaugmentsmetabolicandthermoperceptualresponsivenesstorepeatedwholebodycoldstressinhumans
AT eikenola hypoxiagraduallyaugmentsmetabolicandthermoperceptualresponsivenesstorepeatedwholebodycoldstressinhumans