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Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials

Hierarchical carbohydrate architectures serve multiple roles in nature. Hardly any correlations between the carbohydrate chemical structures and the material properties are available due to the lack of standards and suitable analytic techniques. Therefore, designer carbohydrate materials remain high...

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Autores principales: Gim, Soeun, Fittolani, Giulio, Nishiyama, Yoshiharu, Seeberger, Peter H., Ogawa, Yu, Delbianco, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756587/
https://www.ncbi.nlm.nih.gov/pubmed/32881205
http://dx.doi.org/10.1002/anie.202008153
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author Gim, Soeun
Fittolani, Giulio
Nishiyama, Yoshiharu
Seeberger, Peter H.
Ogawa, Yu
Delbianco, Martina
author_facet Gim, Soeun
Fittolani, Giulio
Nishiyama, Yoshiharu
Seeberger, Peter H.
Ogawa, Yu
Delbianco, Martina
author_sort Gim, Soeun
collection PubMed
description Hierarchical carbohydrate architectures serve multiple roles in nature. Hardly any correlations between the carbohydrate chemical structures and the material properties are available due to the lack of standards and suitable analytic techniques. Therefore, designer carbohydrate materials remain highly unexplored, as compared to peptides and nucleic acids. A synthetic d‐glucose disaccharide, DD, was chosen as a model to explore carbohydrate materials. Microcrystal electron diffraction (MicroED), optimized for oligosaccharides, revealed that DD assembled into highly crystalline left‐handed helical fibers. The supramolecular architecture was correlated to the local crystal organization, allowing for the design of the enantiomeric right‐handed fibers, based on the l‐glucose disaccharide, LL, or flat lamellae, based on the racemic mixture. Tunable morphologies and mechanical properties suggest the potential of carbohydrate materials for nanotechnology applications.
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spelling pubmed-77565872020-12-28 Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials Gim, Soeun Fittolani, Giulio Nishiyama, Yoshiharu Seeberger, Peter H. Ogawa, Yu Delbianco, Martina Angew Chem Int Ed Engl Research Articles Hierarchical carbohydrate architectures serve multiple roles in nature. Hardly any correlations between the carbohydrate chemical structures and the material properties are available due to the lack of standards and suitable analytic techniques. Therefore, designer carbohydrate materials remain highly unexplored, as compared to peptides and nucleic acids. A synthetic d‐glucose disaccharide, DD, was chosen as a model to explore carbohydrate materials. Microcrystal electron diffraction (MicroED), optimized for oligosaccharides, revealed that DD assembled into highly crystalline left‐handed helical fibers. The supramolecular architecture was correlated to the local crystal organization, allowing for the design of the enantiomeric right‐handed fibers, based on the l‐glucose disaccharide, LL, or flat lamellae, based on the racemic mixture. Tunable morphologies and mechanical properties suggest the potential of carbohydrate materials for nanotechnology applications. John Wiley and Sons Inc. 2020-10-07 2020-12-07 /pmc/articles/PMC7756587/ /pubmed/32881205 http://dx.doi.org/10.1002/anie.202008153 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Gim, Soeun
Fittolani, Giulio
Nishiyama, Yoshiharu
Seeberger, Peter H.
Ogawa, Yu
Delbianco, Martina
Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials
title Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials
title_full Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials
title_fullStr Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials
title_full_unstemmed Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials
title_short Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials
title_sort supramolecular assembly and chirality of synthetic carbohydrate materials
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756587/
https://www.ncbi.nlm.nih.gov/pubmed/32881205
http://dx.doi.org/10.1002/anie.202008153
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