Rapid Access to Dispirocyclic Scaffolds Enabled by Diastereoselective Intramolecular Double Functionalization of Benzene Rings

Here we describe the diastereoselective synthesis of (5r,8r)‐1,9‐diazadispiro[4.2.4(8).2(5)]tetradecatrienes via domino double spirocyclization of N‐arylamide derivatives. This reaction can serve as a fast way to synthesize diazadispirocycles, which are found in the core structures of bioactive natu...

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Detalles Bibliográficos
Autores principales: Yokoe, Hiromasa, Mizumura, Yuka, Sugiyama, Kana, Yan, Kejia, Hashizume, Yuna, Endo, Yuto, Yoshida, Sae, Kiriyama, Akiko, Tsubuki, Masayoshi, Kanoh, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756633/
https://www.ncbi.nlm.nih.gov/pubmed/33029940
http://dx.doi.org/10.1002/asia.202001179

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