Cargando…
Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden
BACKGROUND: Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID‐19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID‐19 admitted to ICU. METHODS: We included all 260 patients with COVID‐19 admitted to nine...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756749/ https://www.ncbi.nlm.nih.gov/pubmed/32892337 http://dx.doi.org/10.1111/aas.13694 |
_version_ | 1783626609436131328 |
---|---|
author | Larsson, Emma Brattström, Olof Agvald‐Öhman, Christina Grip, Jonathan Campoccia Jalde, Francesca Strålin, Kristoffer Nauclér, Pontus Oldner, Anders Konrad, David Persson, Björn P. Eriksson, Lars I. Mårtensson, Johan |
author_facet | Larsson, Emma Brattström, Olof Agvald‐Öhman, Christina Grip, Jonathan Campoccia Jalde, Francesca Strålin, Kristoffer Nauclér, Pontus Oldner, Anders Konrad, David Persson, Björn P. Eriksson, Lars I. Mårtensson, Johan |
author_sort | Larsson, Emma |
collection | PubMed |
description | BACKGROUND: Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID‐19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID‐19 admitted to ICU. METHODS: We included all 260 patients with COVID‐19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in‐hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination. RESULTS: Of 260 ICU patients with COVID‐19, 208 (80.0%) were men, the median age was 59 (IQR 51‐65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8‐14) days. Sixty‐two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6‐18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality. CONCLUSION: This study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID‐19 admitted to ICU in a large tertiary hospital in Sweden. |
format | Online Article Text |
id | pubmed-7756749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77567492020-12-28 Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden Larsson, Emma Brattström, Olof Agvald‐Öhman, Christina Grip, Jonathan Campoccia Jalde, Francesca Strålin, Kristoffer Nauclér, Pontus Oldner, Anders Konrad, David Persson, Björn P. Eriksson, Lars I. Mårtensson, Johan Acta Anaesthesiol Scand Intensive Care and Physiology BACKGROUND: Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID‐19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID‐19 admitted to ICU. METHODS: We included all 260 patients with COVID‐19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in‐hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination. RESULTS: Of 260 ICU patients with COVID‐19, 208 (80.0%) were men, the median age was 59 (IQR 51‐65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8‐14) days. Sixty‐two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6‐18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality. CONCLUSION: This study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID‐19 admitted to ICU in a large tertiary hospital in Sweden. John Wiley and Sons Inc. 2020-09-15 2021-01 /pmc/articles/PMC7756749/ /pubmed/32892337 http://dx.doi.org/10.1111/aas.13694 Text en © 2020 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Intensive Care and Physiology Larsson, Emma Brattström, Olof Agvald‐Öhman, Christina Grip, Jonathan Campoccia Jalde, Francesca Strålin, Kristoffer Nauclér, Pontus Oldner, Anders Konrad, David Persson, Björn P. Eriksson, Lars I. Mårtensson, Johan Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden |
title | Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden |
title_full | Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden |
title_fullStr | Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden |
title_full_unstemmed | Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden |
title_short | Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden |
title_sort | characteristics and outcomes of patients with covid‐19 admitted to icu in a tertiary hospital in stockholm, sweden |
topic | Intensive Care and Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756749/ https://www.ncbi.nlm.nih.gov/pubmed/32892337 http://dx.doi.org/10.1111/aas.13694 |
work_keys_str_mv | AT larssonemma characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT brattstromolof characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT agvaldohmanchristina characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT gripjonathan characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT campocciajaldefrancesca characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT stralinkristoffer characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT nauclerpontus characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT oldneranders characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT konraddavid characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT perssonbjornp characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT erikssonlarsi characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT martenssonjohan characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden AT characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden |