Cargando…

Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden

BACKGROUND: Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID‐19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID‐19 admitted to ICU. METHODS: We included all 260 patients with COVID‐19 admitted to nine...

Descripción completa

Detalles Bibliográficos
Autores principales: Larsson, Emma, Brattström, Olof, Agvald‐Öhman, Christina, Grip, Jonathan, Campoccia Jalde, Francesca, Strålin, Kristoffer, Nauclér, Pontus, Oldner, Anders, Konrad, David, Persson, Björn P., Eriksson, Lars I., Mårtensson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756749/
https://www.ncbi.nlm.nih.gov/pubmed/32892337
http://dx.doi.org/10.1111/aas.13694
_version_ 1783626609436131328
author Larsson, Emma
Brattström, Olof
Agvald‐Öhman, Christina
Grip, Jonathan
Campoccia Jalde, Francesca
Strålin, Kristoffer
Nauclér, Pontus
Oldner, Anders
Konrad, David
Persson, Björn P.
Eriksson, Lars I.
Mårtensson, Johan
author_facet Larsson, Emma
Brattström, Olof
Agvald‐Öhman, Christina
Grip, Jonathan
Campoccia Jalde, Francesca
Strålin, Kristoffer
Nauclér, Pontus
Oldner, Anders
Konrad, David
Persson, Björn P.
Eriksson, Lars I.
Mårtensson, Johan
author_sort Larsson, Emma
collection PubMed
description BACKGROUND: Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID‐19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID‐19 admitted to ICU. METHODS: We included all 260 patients with COVID‐19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in‐hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination. RESULTS: Of 260 ICU patients with COVID‐19, 208 (80.0%) were men, the median age was 59 (IQR 51‐65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8‐14) days. Sixty‐two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6‐18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality. CONCLUSION: This study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID‐19 admitted to ICU in a large tertiary hospital in Sweden.
format Online
Article
Text
id pubmed-7756749
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-77567492020-12-28 Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden Larsson, Emma Brattström, Olof Agvald‐Öhman, Christina Grip, Jonathan Campoccia Jalde, Francesca Strålin, Kristoffer Nauclér, Pontus Oldner, Anders Konrad, David Persson, Björn P. Eriksson, Lars I. Mårtensson, Johan Acta Anaesthesiol Scand Intensive Care and Physiology BACKGROUND: Information on characteristics and outcomes of intensive care unit (ICU) patients with COVID‐19 remains limited. We examined characteristics, clinical course and early outcomes of patients with COVID‐19 admitted to ICU. METHODS: We included all 260 patients with COVID‐19 admitted to nine ICUs at the Karolinska University Hospital (Stockholm, Sweden) between 9 March and 20 April 2020. Primary outcome was in‐hospital mortality among patients with definite outcomes (discharged from ICU or death), as of 30 April 2020 (study end point). Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination. RESULTS: Of 260 ICU patients with COVID‐19, 208 (80.0%) were men, the median age was 59 (IQR 51‐65) years, 154 (59.2%) had at least one comorbidity, and the median duration of symptoms preceding ICU admission was 11 (IQR 8‐14) days. Sixty‐two (23.8%) patients remained in ICU at study end point. Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6‐18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. On multivariable logistic regression analysis, older age and admission from the emergency department was associated with higher mortality. CONCLUSION: This study presents detailed data on clinical characteristics and early outcomes of consecutive patients with COVID‐19 admitted to ICU in a large tertiary hospital in Sweden. John Wiley and Sons Inc. 2020-09-15 2021-01 /pmc/articles/PMC7756749/ /pubmed/32892337 http://dx.doi.org/10.1111/aas.13694 Text en © 2020 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Intensive Care and Physiology
Larsson, Emma
Brattström, Olof
Agvald‐Öhman, Christina
Grip, Jonathan
Campoccia Jalde, Francesca
Strålin, Kristoffer
Nauclér, Pontus
Oldner, Anders
Konrad, David
Persson, Björn P.
Eriksson, Lars I.
Mårtensson, Johan
Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden
title Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden
title_full Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden
title_fullStr Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden
title_full_unstemmed Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden
title_short Characteristics and outcomes of patients with COVID‐19 admitted to ICU in a tertiary hospital in Stockholm, Sweden
title_sort characteristics and outcomes of patients with covid‐19 admitted to icu in a tertiary hospital in stockholm, sweden
topic Intensive Care and Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756749/
https://www.ncbi.nlm.nih.gov/pubmed/32892337
http://dx.doi.org/10.1111/aas.13694
work_keys_str_mv AT larssonemma characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT brattstromolof characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT agvaldohmanchristina characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT gripjonathan characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT campocciajaldefrancesca characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT stralinkristoffer characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT nauclerpontus characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT oldneranders characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT konraddavid characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT perssonbjornp characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT erikssonlarsi characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT martenssonjohan characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden
AT characteristicsandoutcomesofpatientswithcovid19admittedtoicuinatertiaryhospitalinstockholmsweden